Protein detail
KGUA
Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)
Entry name KGUA | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 23 | Transmembrane count | Protein classification EnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1)
Protein Class (4)
EnzymesEssential proteinsMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Guanylate kinase 1
Chromosome
1
Position
228139962-228148984
Supporting publications (n)
23
EVMP confidence score
0.75
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway7
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
KEGG (3)
Reactome (4)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence7
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 40595564 |
Sequence, Structure & Domains12
Sequences
Length
197
Mass
21,726
Sequence
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16774-1; Sequence=Displayed; Name=2; IsoId=Q16774-2; Sequence=VSP_043778; Name=3; IsoId=Q16774-3; Sequence=VSP_043778, VSP_047372
Alternative Sequence
1; M -> MLRRPLAGLAAAALGRAPPDGM (in isoform 2 and isoform 3); 159..197; SKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA -> RNQESSKDRRLRLAVCSRHPGPIQDQGSSIEPPPWQAIRQLCALGQHVEWRRCCPCGWNILG (in isoform 3)
3D Structural Models
Turn
29..31; 49..51; 162..164
Helix
17..27; 58..67; 85..93; 104..111; 127..137; 142..158; 174..193
Beta Strand
7..11; 12..14; 32..34; 38..41; 70..76; 79..84; 97..101; 118..123; 166..170
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
4..186; Guanylate kinase-like
Protein Families
Guanylate kinase family
Sequence Similarities
Belongs to the guanylate kinase family.
Clinical Relevance2
Disease Involvement
Disease variant
Antibody
Supporting Publications23
| PMID | Title | Abstract |
|---|---|---|
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 34064456 | Characterization of Extracellular Vesicle Cargo in Sjögren's Syndrome through a SWATH-MS Proteomics Approach. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |
| 38564289 | Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer. | No abstract available |
| 39436214 | Human ovarian extracellular vesicles proteome from polycystic ovary syndrome patients associate with follicular development alterations. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No abstract available |
| 40545963 | Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer. | No abstract available |