Protein detail

ECSCR

Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)

Entry name ECSCR	UniProt ID Q19T08	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)

Transmembrane

125..145; Helical

Transmembrane Count

Ensembl

ENSG00000249751

Entrez Gene Symbol

ECSCR

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization6

Tissue SpecificepididymisCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway5

Cellular Component (4)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Canonical Pathways (2)

M137 Pid vegf vegfr pathway
M226 Pid vegfr1 pathway

Mediation Categories

Other mediation

Relations & Evidence17

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	4	39290459 29562735 41201090 35085587

Sequence, Structure & Domains7

Sequences

Length

205

Mass

21,295

Sequence

MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL

Domain & Motif Annotations

Compositional Bias

49..71; Polar residues; 86..101; Polar residues; 163..175; Polar residues

Region

49..101; Disordered; 153..175; Disordered

Protein Families

ECSCR family

Sequence Similarities

Belongs to the ECSCR family.

Supporting Publications2

PMID	Title	Abstract
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available