Protein detail

ECSCR

Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)

Entry name
ECSCR
UniProt ID
Q19T08
EVMP confidence score
0.53
Supporting publications (n)
2
Transmembrane count
1
Protein classification
Basic Information
Protein Names
Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)
Transmembrane
125..145; Helical
Transmembrane Count
1
Ensembl
ENSG00000249751
Entrez Gene Symbol
ECSCR
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
ECSCR fluorescence
Tissue SpecificepididymisCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Cellular Component (4)
Molecular Function
GO:0005515 protein binding
Biological Process (3)
Canonical Pathways (2)
  • M137 Pid vegf vegfr pathway
  • M226 Pid vegfr1 pathway
Mediation Categories
Other mediation
Relations & Evidence17

Ligand-Receptor Signaling (16)

16 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPIYes
intracellularintracellularGO_IntercellYes
intracellularintracellularUniProt_locationYes
intracellularintracellularOmniPathYes
transmembranetransmembraneUniProt_locationYes
transmembranetransmembraneUniProt_topologyYes
transmembranetransmembraneUniProt_keywordYes
transmembranetransmembraneRamilowski_locationYes
transmembranetransmembraneOmniPathYes
plasma_membraneplasma_membraneUniProt_locationYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryWestern blotting439290459295627354120109035085587
Sequence, Structure & Domains

Sequences

Length
205
Mass
21,295
Sequence
MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL

Domain & Motif Annotations

Compositional Bias
49..71; Polar residues; 86..101; Polar residues; 163..175; Polar residues
Region
49..101; Disordered; 153..175; Disordered
Protein Families
ECSCR family
Sequence Similarities
Belongs to the ECSCR family.
Supporting Publications2
PMIDTitleRelated sentences
34817906Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.No related sentences available
35611462Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.No related sentences available