Protein detail

ECSCR

Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)

Protein symbol ECSCR	UniProt ID Q19T08	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)

Transmembrane

125..145; Helical

Transmembrane Count

Ensembl

ENSG00000249751

Entrez Gene Symbol

ECSCR

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificepididymisCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Canonical Pathways

M137 Pid vegf vegfr pathway
M226 Pid vegfr1 pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

Page 2 of 2Previous

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	4	39290459 29562735 41201090 35085587

Sequence, Structure & Domains

Sequences

Length

205

Mass

21,295

Sequence

MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLTTEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL

3D Structural Models

Domain & Motif Annotations

Compositional Bias

49..71; Polar residues; 86..101; Polar residues; 163..175; Polar residues

Region

49..101; Disordered; 153..175; Disordered

Protein Families

ECSCR family

Sequence Similarities

Belongs to the ECSCR family.

Clinical Relevance