Protein detail
MICB
MHC class I polypeptide-related sequence B (MIC-B)
Entry name MICB | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
MHC class I polypeptide-related sequence B (MIC-B)
Protein Function
Disease related genes
Transmembrane
310..330; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
383
Mass
42,575
Sequence
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=MICB1; IsoId=Q29980-1; Sequence=Displayed; Name=2; Synonyms=MICB2, ex3-del; IsoId=Q29980-2; Sequence=VSP_055246; Name=3; IsoId=Q29980-3; Sequence=VSP_052801, VSP_052802
Alternative Sequence
24..41; EPHSLRYNLMVLSQDGSV -> VEMGFHRVSQDGLDLLTS (in isoform 3); 42..383; Missing (in isoform 3); 109..151; Missing (in isoform 2)
3D Structural Models
Turn
61..64; 145..147
Helix
71..75; 80..101; 156..170; 176..197; 201..203; 277..279
Beta Strand
26..37; 46..51; 54..60; 65..68; 104..106; 109..121; 123..125; 127..135; 138..144; 208..214; 218..233; 236..241; 250..253; 264..273; 280..286; 289..294
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
207..298; Ig-like C1-type
Protein Families
- MHC class I family
- MIC subfamily
Sequence Similarities
Belongs to the MHC class I family. MIC subfamily.