Protein detail
MICB
MHC class I polypeptide-related sequence B (MIC-B)
Entry name MICB | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
MHC class I polypeptide-related sequence B (MIC-B)
Protein Function
Disease related genes
Transmembrane
310..330; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway7
Protein Function
Disease related genes
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
KEGG (2)
Reactome (2)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence41
Ligand-Receptor Signaling (39)
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains12
Sequences
Length
383
Mass
42,575
Sequence
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=MICB1; IsoId=Q29980-1; Sequence=Displayed; Name=2; Synonyms=MICB2, ex3-del; IsoId=Q29980-2; Sequence=VSP_055246; Name=3; IsoId=Q29980-3; Sequence=VSP_052801, VSP_052802
Alternative Sequence
24..41; EPHSLRYNLMVLSQDGSV -> VEMGFHRVSQDGLDLLTS (in isoform 3); 42..383; Missing (in isoform 3); 109..151; Missing (in isoform 2)
3D Structural Models
Turn
61..64; 145..147
Helix
71..75; 80..101; 156..170; 176..197; 201..203; 277..279
Beta Strand
26..37; 46..51; 54..60; 65..68; 104..106; 109..121; 123..125; 127..135; 138..144; 208..214; 218..233; 236..241; 250..253; 264..273; 280..286; 289..294
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
207..298; Ig-like C1-type
Protein Families (2)
- MHC class I family
- MIC subfamily
Sequence Similarities
Belongs to the MHC class I family. MIC subfamily.
Clinical Relevance1
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |