Protein detail
MICA
MHC class I polypeptide-related sequence A (MIC-A)
Entry name MICA | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
MHC class I polypeptide-related sequence A (MIC-A)
Protein Function
Predicted intracellular proteins
Transmembrane
308..328; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway8
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
KEGG (2)
Reactome (2)
Canonical Pathways (2)
- M82 Pid ret pathway
- M142 Pid ajdiss 2pathway
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence54
Ligand-Receptor Signaling (42)
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | Yes | No |
Protein Complex Composition (11)
11 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MICAL2RAB10 | O94851P61026 | 1:1 | PDB | PDB:5szj | ||
| MICAL2RAB1B | O94851Q9H0U4 | 1:1 | PDB | PDB:5szhPDB:5szk | ||
| MICAL1RAB10 | P61026Q8TDZ2 | 2:1 | PDB | PDB:9g0dPDB:9g0cPDB:5lpn | ||
| KIF23MICAL3RACGAP1SHCBP1 | Q02241Q7RTP6Q8NEM2Q9H0H5 | 0:0:0:0 | hu.MAP | |||
| MDC1MICALL1RTKN2SH3KBP1STAP1 | Q14676Q8IZC4Q8N3F8Q96B97Q9ULZ2 | 0:0:0:0:0 | hu.MAP2 | |||
| MDC1MICALL1RTKN2SH3BP1SH3KBP1 | Q14676Q8IZC4Q8N3F8Q96B97Q9Y3L3 | 0:0:0:0:0 | hu.MAP2 | |||
| MICA | Q29983 | 2 | PDB | PDB:8tlz | ||
| MICAPHF7 | Q29983Q9BWX1 | 0:0 | hu.MAP | |||
| CERKLMICAL3 | Q49MI3Q7RTP6 | 0:0 | hu.MAP2 | |||
| MICAL3 | Q7RTP6 | 2 | PDB | PDB:5szg |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains12
Sequences
Length
383
Mass
42,915
Sequence
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MICA1; IsoId=Q29983-1; Sequence=Displayed; Name=2; Synonyms=MICA2; IsoId=Q29983-2; Sequence=VSP_055366
Alternative Sequence
109..204; Missing (in isoform 2)
3D Structural Models
Turn
87..90; 145..148; 198..200
Helix
79..81; 83..86; 91..101; 156..171; 177..197; 217..219; 248..250; 277..279
Beta Strand
26..37; 46..51; 54..60; 63..65; 71..75; 109..121; 127..135; 138..144; 149..151; 208..214; 220..233; 236..241; 251..253; 260..262; 264..273; 280..286; 289..294
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Domain (FT)
207..296; Ig-like C1-type
Protein Families (2)
- MHC class I family
- MIC subfamily
Sequence Similarities
Belongs to the MHC class I family. MIC subfamily.
Clinical Relevance1
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No abstract available |