EV MemProt Atlas

Basic Information

Protein Names

MHC class I polypeptide-related sequence A (MIC-A)

Protein Function

Predicted intracellular proteins

Transmembrane

308..328; Helical

Transmembrane Count

1

Ensembl

ENSG00000204520

Entrez Gene Symbol

MICA

Frequency

1

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M82 Pid ret pathway
M142 Pid ajdiss 2pathway

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	LOCATE	No	No	Yes	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	Yes	Yes	No
transmembrane	transmembrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	Yes	Yes	No
secreted	secreted	connectomeDB2020	No	No	Yes	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

11 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MICAL2 RAB10	O94851 P61026	1:1	PDB	PDB:5szj
MICAL2 RAB1B	O94851 Q9H0U4	1:1	PDB	PDB:5szhPDB:5szk
MICAL1 RAB10	P61026 Q8TDZ2	2:1	PDB	PDB:9g0dPDB:9g0cPDB:5lpn
KIF23 MICAL3 RACGAP1 SHCBP1	Q02241 Q7RTP6 Q8NEM2 Q9H0H5	0:0:0:0	hu.MAP
MDC1 MICALL1 RTKN2 SH3KBP1 STAP1	Q14676 Q8IZC4 Q8N3F8 Q96B97 Q9ULZ2	0:0:0:0:0	hu.MAP2
MDC1 MICALL1 RTKN2 SH3BP1 SH3KBP1	Q14676 Q8IZC4 Q8N3F8 Q96B97 Q9Y3L3	0:0:0:0:0	hu.MAP2
MICA	Q29983	2	PDB	PDB:8tlz
MICA PHF7	Q29983 Q9BWX1	0:0	hu.MAP
CERKL MICAL3	Q49MI3 Q7RTP6	0:0	hu.MAP2
MICAL3	Q7RTP6	2	PDB	PDB:5szg

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

383

Mass

42,915

Sequence

MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MICA1; IsoId=Q29983-1; Sequence=Displayed; Name=2; Synonyms=MICA2; IsoId=Q29983-2; Sequence=VSP_055366

Alternative Sequence

109..204; Missing (in isoform 2)

3D Structural Models

Turn

87..90; 145..148; 198..200

Helix

79..81; 83..86; 91..101; 156..171; 177..197; 217..219; 248..250; 277..279

Beta Strand

26..37; 46..51; 54..60; 63..65; 71..75; 109..121; 127..135; 138..144; 149..151; 208..214; 220..233; 236..241; 251..253; 260..262; 264..273; 280..286; 289..294

3D Structure

X-ray crystallography (10)

Domain & Motif Annotations

Domain (FT)

207..296; Ig-like C1-type

Protein Families

MHC class I family
MIC subfamily

Sequence Similarities

Belongs to the MHC class I family. MIC subfamily.

Clinical Relevance

Drugs

RECOMBINANT 70-KD HEAT-SHOCK PROTEIN CARBAMAZEPINE NULL

Protein symbol MICA	UniProt ID Q29983	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification