Protein detail

S4A8

Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)

Entry name S4A8	UniProt ID Q2Y0W8	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count 11	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

479..499; Helical; 524..544; Helical; 566..586; Helical; 596..616; Helical; 688..708; Helical; 732..752; Helical; 779..799; Helical; 825..845; Helical; 882..902; Helical; 905..925; Helical; 963..983; Helical

Transmembrane Count

Ensembl

ENSG00000050438

Entrez Gene Symbol

SLC4A8

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (18)

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Molecular Function (8)

Biological Process (3)

Reactome (4)

Canonical Pathways

M286 Pid tgfbr pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence32

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
apc	transporter	Surfaceome	No	Yes	No	No	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ABCB7 NSF RGS9 SLC4A8	O75027 O75916 P46459 Q2Y0W8	1:1:1:1	NetworkBlastCompleat	Compleat:HC9179
ABCB7 F10 F7 NSF SLC4A8	O75027 P00742 P08709 P46459 Q2Y0W8	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6215
SLC4A8	Q2Y0W8	2	PDB	PDB:5jho

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	32795414

Sequence, Structure & Domains15

Sequences

Length

1,093

Mass

122,938

Sequence

MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKAKEEEEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFN

Alternative Products

Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=NDCBE-A; IsoId=Q2Y0W8-1; Sequence=Displayed; Name=2; IsoId=Q2Y0W8-2; Sequence=VSP_052760, VSP_052765; Name=3; Synonyms=NDCBE-B; IsoId=Q2Y0W8-3; Sequence=VSP_052765; Name=4; Synonyms=NDCBE-D; IsoId=Q2Y0W8-4; Sequence=VSP_052759, VSP_052765; Name=5; Synonyms=NDCBE-C; IsoId=Q2Y0W8-5; Sequence=VSP_052759; Name=6; IsoId=Q2Y0W8-6; Sequence=VSP_052761, VSP_052762; Name=7; IsoId=Q2Y0W8-7; Sequence=VSP_052759, VSP_052763, VSP_052764; Name=8; IsoId=Q2Y0W8-8; Sequence=VSP_052759, VSP_052761, VSP_052762

Alternative Sequence

1..53; Missing (in isoform 4, isoform 5, isoform 7 and isoform 8); 1..16; MPAAGSNEPDGVLSYQ -> MFNKNNSNKLRSTPRYRRGDPGYLNFTELGPLKPEQKDQWSQH (in isoform 2); 671..691; ECQEMHGEFMGSACGHHGPYT -> VSLGAARCPSIVTTGLGGTSK (in isoform 6 and isoform 8); 692..1093; Missing (in isoform 6 and isoform 8); 725..800; VRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMD -> MESCSVAWLECGGVILAHCNLRLLPSSWDYRHAPPQPANFCIFSRDGVSPCWPGWSQSLDLVICLPRPPKMLGLQA (in isoform 7); 801..1093; Missing (in isoform 7); 1028..1093; EAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFN -> VIVLAPTVYLGASNYRT (in isoform 2, isoform 3 and isoform 4)

3D Structural Models

Turn

198..201; 328..330

Helix

98..104; 148..150; 163..175; 187..195; 206..216; 291..293; 350..363; 367..375; 379..392

Beta Strand

116..125; 133..147; 176..182; 202..204; 299..308; 315..325; 331..333; 337..345; 394..396

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

59..77; Basic residues

Motif

Q2Y0W8-4:340..344; VTVLP; mediates dimerization

Coiled Coil

1010..1036

Region

1..25; Disordered; 55..95; Disordered

Protein Families

Anion exchanger (TC 2.A.31) family

Sequence Similarities

Belongs to the anion exchanger (TC 2.A.31) family.

Clinical Relevance1

Drugs

DEHYDRATED ALCOHOL

Supporting Publications5

PMID	Title	Abstract
27903962	Targeted proteomics in urinary extracellular vesicles identifies biomarkers for diagnosis and prognosis of prostate cancer.	Here, we describe a set of protein-combination panels in urinary extracellular vesicles (EVs), defined by targeted proteomics and immunoblotting techniques that improve early non-invasive detection and stratification of PCa patients.We report a two-protein combination in urinary EVs that classifies benign and PCa patients (ADSV-TGM4), and a combination of five proteins able to significantly distinguish between high- and low-grade PCa patients (CD63-GLPK5-SPHM-PSA-PAPP).
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available