Protein detail
S4A8
Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)
Protein symbol S4A8 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 11 | Protein classification |
Basic Information
Protein Names
Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
479..499; Helical; 524..544; Helical; 566..586; Helical; 596..616; Helical; 688..708; Helical; 732..752; Helical; 779..799; Helical; 825..845; Helical; 882..902; Helical; 905..925; Helical; 963..983; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030425 dendrite
- GO:0030672 synaptic vesicle membrane
- GO:0032279 asymmetric synapse
- GO:0032280 symmetric synapse
- GO:0032809 neuronal cell body membrane
- GO:0042734 presynaptic membrane
- GO:0043005 neuron projection
- GO:0043195 terminal bouton
- GO:0043679 axon terminus
- GO:0097386 glial cell projection
- GO:0097457 hippocampal mossy fiber
- GO:0098793 presynapse
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0005452 solute:inorganic anion antiporter activity
- GO:0008270 zinc ion binding
- GO:0008510 sodium:bicarbonate symporter activity
- GO:0015081 sodium ion transmembrane transporter activity
- GO:0015106 bicarbonate transmembrane transporter activity
- GO:0015108 chloride transmembrane transporter activity
- GO:0042802 identical protein binding
- GO:0140892 sodium,bicarbonate:chloride antiporter activity
Biological Process
Reactome
Canonical Pathways
M286 Pid tgfbr pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| slc4 | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ABCB7NSFRGS9SLC4A8 | O75027O75916P46459Q2Y0W8 | 1:1:1:1 | NetworkBlastCompleat | Compleat:HC9179 | ||
| ABCB7F10F7NSFSLC4A8 | O75027P00742P08709P46459Q2Y0W8 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6215 | ||
| SLC4A8 | Q2Y0W8 | 2 | PDB | PDB:5jho |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 32795414 |
Sequence, Structure & Domains
Sequences
Length
1,093
Mass
122,938
Sequence
MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKAKEEEEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFN
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=NDCBE-A; IsoId=Q2Y0W8-1; Sequence=Displayed; Name=2; IsoId=Q2Y0W8-2; Sequence=VSP_052760, VSP_052765; Name=3; Synonyms=NDCBE-B; IsoId=Q2Y0W8-3; Sequence=VSP_052765; Name=4; Synonyms=NDCBE-D; IsoId=Q2Y0W8-4; Sequence=VSP_052759, VSP_052765; Name=5; Synonyms=NDCBE-C; IsoId=Q2Y0W8-5; Sequence=VSP_052759; Name=6; IsoId=Q2Y0W8-6; Sequence=VSP_052761, VSP_052762; Name=7; IsoId=Q2Y0W8-7; Sequence=VSP_052759, VSP_052763, VSP_052764; Name=8; IsoId=Q2Y0W8-8; Sequence=VSP_052759, VSP_052761, VSP_052762
Alternative Sequence
1..53; Missing (in isoform 4, isoform 5, isoform 7 and isoform 8); 1..16; MPAAGSNEPDGVLSYQ -> MFNKNNSNKLRSTPRYRRGDPGYLNFTELGPLKPEQKDQWSQH (in isoform 2); 671..691; ECQEMHGEFMGSACGHHGPYT -> VSLGAARCPSIVTTGLGGTSK (in isoform 6 and isoform 8); 692..1093; Missing (in isoform 6 and isoform 8); 725..800; VRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMD -> MESCSVAWLECGGVILAHCNLRLLPSSWDYRHAPPQPANFCIFSRDGVSPCWPGWSQSLDLVICLPRPPKMLGLQA (in isoform 7); 801..1093; Missing (in isoform 7); 1028..1093; EAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALSMNSGNAKEKSLFN -> VIVLAPTVYLGASNYRT (in isoform 2, isoform 3 and isoform 4)
3D Structural Models
Turn
198..201; 328..330
Helix
98..104; 148..150; 163..175; 187..195; 206..216; 291..293; 350..363; 367..375; 379..392
Beta Strand
116..125; 133..147; 176..182; 202..204; 299..308; 315..325; 331..333; 337..345; 394..396
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
59..77; Basic residues
Motif
Q2Y0W8-4:340..344; VTVLP; mediates dimerization
Coiled Coil
1010..1036
Region
1..25; Disordered; 55..95; Disordered
Protein Families
Anion exchanger (TC 2.A.31) family
Sequence Similarities
Belongs to the anion exchanger (TC 2.A.31) family.
Clinical Relevance
Drugs