Protein detail

ADCK5

Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-)

Entry name ADCK5	UniProt ID Q3MIX3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification EnzymesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-)

Protein Class (2)

EnzymesPredicted membrane proteins

Protein Function (2)

Enzymes
Kinases:Atypical kinases

Transmembrane

50..67; Helical

Transmembrane Count

Ensembl

ENSG00000173137

Entrez Gene Symbol

ADCK5

Gene Synonym

FLJ35454

Gene Description

AarF domain containing kinase 5

Chromosome

Position

144373101-144393242

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway6

Protein Function (2)

Enzymes
Kinases:Atypical kinases

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Canonical Pathways

M68 Pid rhoa reg pathway

Mediation Categories

Other mediation

Relations & Evidence18

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADCK5	Q3MIX3	SOX9	P48436	Yes	Yes	No	SIGNOR_ProtMapperSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:32277958 ProtMapper:32277958

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ADCK5 JUNB OXSM RGPD3	A6NKT7 P17275 Q3MIX3 Q9NWU1	0:0:0:0	hu.MAP
ADCK5 BATF3 FOS JUNB JUND	P01100 P17275 P17535 Q3MIX3 Q9NR55	0:0:0:0:0	hu.MAP
ADCK5 BATF3 JUNB JUND	P17275 P17535 Q3MIX3 Q9NR55	0:0:0:0	hu.MAP
ADCK5 ATF3 BRCA1 FOSB JUNB	P17275 P18847 P38398 P53539 Q3MIX3	0:0:0:0:0	hu.MAP2
ADCK5 ATF3 FOSB JUNB	P17275 P18847 P53539 Q3MIX3	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western BlottingMass Spectrometry	1	36573687

Sequence, Structure & Domains6

Sequences

Length

580

Mass

65,828

Sequence

MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET

Domain & Motif Annotations

Domain (FT)

179..419; Protein kinase

Protein Families (2)

Protein kinase superfamily
ADCK protein kinase family

Sequence Similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Clinical Relevance1

Antibody (2)

HPA025692 HPA028679

Supporting Publications1

PMID	Title	Abstract
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available