Protein detail

TIGIT

T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)

Protein symbol TIGIT	UniProt ID Q495A1	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification

Basic Information

Protein Names

T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)

Transmembrane

142..162; Helical

Transmembrane Count

Ensembl

ENSG00000181847

Entrez Gene Symbol

TIGIT

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificlungCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Cellular Component

Molecular Function

Biological Process

KEGG

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TIGIT	LCK	P06239	Y	225	phosphorylation	PhosphoSite
TIGIT	FYN	P06241	Y	225	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

36 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
checkpoint	receptor	ICELLNET	No	Yes	No	Yes	No
checkpoint_nectin	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TIGIT	Q495A1	ARRB2	P32121	Yes	Yes	No	InnateDBSIGNOR	InnateDB:24817116 SIGNOR:24817116
PVR	P15151	TIGIT	Q495A1	Yes	Yes	No	CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HINTWojtowicz2020IntActLit-BM-17LRdb	connectomeDB2020:19815499 IntAct:21982860 HINT:21982860 ICELLNET:27192565 HINT:28515320 HINT:22421438 IntAct:28515320 Lit-BM-17:21982860 SIGNOR:30591568
LCK	P06239	TIGIT	Q495A1	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23154388

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TIGIT	Q495A1	2	PDB	PDB:8jenPDB:3rq3PDB:7vytPDB:8jeoPDB:8vtePDB:8szyPDB:3q0hPDB:3ucrPDB:8jel

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry [LTQ-FT Ultra]	12	39290459 34071777 25471207 26801919 30353492 36362114 38490958 39104279 30760538 37922300 40091455 38612515

Sequence, Structure & Domains

Sequences

Length

244

Mass

26,319

Sequence

MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q495A1-1; Sequence=Displayed; Name=2; IsoId=Q495A1-2; Sequence=VSP_027634, VSP_027635

Alternative Sequence

167..170; KKAL -> FVCF (in isoform 2); 171..244; Missing (in isoform 2)

3D Structural Models

Turn

71..73; 82..84

Helix

79..81; 100..102

Beta Strand

26..28; 31..36; 41..43; 46..49; 53..61; 64..70; 74..77; 85..87; 93..95; 104..113; 116..127

3D Structure

X-ray crystallography (11)

Domain & Motif Annotations

Motif

229..234; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

22..124; Ig-like V-type

Region

32..42; Homodimerization

Clinical Relevance

Related Diseases

Cervical cancer Lung cancer Non-small-cell lung cancer Solid tumour/cancer

Biomarker

Phase 2; Phase 3

Drugs

VIBOSTOLIMAB ETIGILIMAB IBI-939 DOMVANALIMAB ANTI-TIGIT MONOCLONAL ANTIBODY ASP8374 ASP-8374 OCIPERLIMAB TIRAGOLUMAB