Protein detail
TIGIT
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
Protein symbol TIGIT | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
Transmembrane
142..162; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificlungCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TIGIT | Q495A1 | ARRB2 | P32121 | Yes | Yes | No | InnateDBSIGNOR | InnateDB:24817116SIGNOR:24817116 |
| PVR | P15151 | TIGIT | Q495A1 | Yes | Yes | No | CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HINTWojtowicz2020IntActLit-BM-17LRdb | connectomeDB2020:19815499IntAct:21982860HINT:21982860ICELLNET:27192565HINT:28515320HINT:22421438IntAct:28515320Lit-BM-17:21982860SIGNOR:30591568 |
| LCK | P06239 | TIGIT | Q495A1 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23154388 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra] | 12 | 392904593407177725471207268019193035349236362114384909583910427930760538379223004009145538612515 |
Sequence, Structure & Domains
Sequences
Length
244
Mass
26,319
Sequence
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q495A1-1; Sequence=Displayed; Name=2; IsoId=Q495A1-2; Sequence=VSP_027634, VSP_027635
Alternative Sequence
167..170; KKAL -> FVCF (in isoform 2); 171..244; Missing (in isoform 2)
3D Structural Models
Turn
71..73; 82..84
Helix
79..81; 100..102
Beta Strand
26..28; 31..36; 41..43; 46..49; 53..61; 64..70; 74..77; 85..87; 93..95; 104..113; 116..127
3D Structure
X-ray crystallography (11)
Domain & Motif Annotations
Motif
229..234; ITIM motif
Domain (CC)
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain (FT)
22..124; Ig-like V-type
Region
32..42; Homodimerization
Clinical Relevance
Biomarker
Phase 2; Phase 3