Protein detail

CDON

Cell adhesion molecule-related/down-regulated by oncogenes

Entry name CDON	UniProt ID Q4KMG0	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Cell adhesion molecule-related/down-regulated by oncogenes

Protein Class (3)

Disease related genesHuman disease related genesPredicted membrane proteins

Protein Function (2)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system

Transmembrane

964..984; Helical

Transmembrane Count

Ensembl

ENSG00000064309

Entrez Gene Symbol

CDON

Gene Synonym (4)

CDOCDON1IhogORCAM

Gene Description

Cell adhesion associated, oncogene regulated

Chromosome

Position

125955796-126063335

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization6

Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificupper rhombic lipSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein

Function & Pathway7

Protein Function (2)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG

hsa04340 Hedgehog signaling pathway

Reactome (5)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence67

Ligand-Receptor Signaling (55)

55 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
ig_like	receptor	Almen2009	No	Yes	No	Yes	No
netrin	receptor	Almen2009	No	Yes	No	Yes	No
netrin	receptor	HPMR	No	Yes	No	Yes	No
dcc	receptor	HPMR	No	Yes	No	Yes	No

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CAD15	P55291	CDON	Q4KMG0	Yes	Yes	No	HPRDSIGNOR	SIGNOR:12634428 HPRD:12634428
CDON	Q4KMG0	ABL1	P00519	Yes	Yes	No	Lit-BM-17SIGNOR	Lit-BM-17:19470755 SIGNOR:19470755
CADH2	P19022	CDON	Q4KMG0	Yes	Yes	No	HPRDSIGNOR	SIGNOR:20160094 HPRD:12634428
CDON	Q4KMG0	JIP4	O60271	Yes	Yes	No	SIGNOR	SIGNOR:17074887 SIGNOR:18678706
CDON	Q4KMG0	MK14	Q16539	Yes	Yes	No	SIGNOR	SIGNOR:18678706
CDON	Q4KMG0	BNIP2	Q12982	Yes	Yes	No	SIGNOR	SIGNOR:18678706

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CDON/SPAG9	CDON SPAG9	O60271 Q4KMG0	0:0	SIGNOR	SIGNOR:SIGNOR-C21
PTCH2_CDON_transmembrane_receptor	CDON PTCH2	Q4KMG0 Q9Y6C5	1:1	CellPhoneDB	CellPhoneDB:PTCH2_CDON_transmembrane_receptor
	CDON DHH	O43323 Q4KMG0	3:3	PDB	PDB:3n1q
	CDON DCBLD1 TNFSF8	P32971 Q4KMG0 Q8N8Z6	0:0:0	hu.MAP2
	CDON IHH	Q14623 Q4KMG0	2:2	PDB	PDB:3n1f

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Small R sequencing (Illumi HiSeq 2000 (Solexa)	2	39290459 37686366

Sequence, Structure & Domains11

Sequences

Length

1,287

Mass

139,147

Sequence

MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPRET

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4KMG0-1; Sequence=Displayed; Name=2; IsoId=Q4KMG0-2; Sequence=VSP_018201

Alternative Sequence

1212..1234; Missing (in isoform 2)

3D Structural Models

Helix

852..854; 874..876

Beta Strand

831..837; 839..841; 843..848; 861..868; 878..883; 887..891; 899..908; 919..922

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

537..546; Basic and acidic residues

Domain (FT)

29..114; Ig-like C2-type 1; 120..204; Ig-like C2-type 2; 225..303; Ig-like C2-type 3; 310..396; Ig-like C2-type 4; 405..516; Ig-like C2-type 5; 579..677; Fibronectin type-III 1; 723..821; Fibronectin type-III 2; 826..926; Fibronectin type-III 3

Region

531..553; Disordered; 933..955; Disordered; 1268..1287; Disordered

Clinical Relevance2

Disease Involvement (2)

Disease variantHoloprosencephaly

Antibody (2)

CAB012422 HPA017377

Supporting Publications1

PMID	Title	Abstract
12645951	Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59.	Exosomes express the glycosylphosphatidylinositol (GPI)-anchored regulators CD55 and CD59, but not the transmembrane protein CD46. We conclude that exosomes express GPI-anchored complement regulators in order to permit their survival in the extracellular environment. We have examined the expression and functional roles of the membrane regulators of complement (CD46, CD55 and CD59) on antigen-presenting cell-derived exosomes.