Protein detail
CDON
Cell adhesion molecule-related/down-regulated by oncogenes
Protein symbol CDON | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
Basic Information
Protein Names
Cell adhesion molecule-related/down-regulated by oncogenes
Protein Class
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Transmembrane
964..984; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDOCDON1IhogORCAM
Gene Description
Cell adhesion associated, oncogene regulated
Chromosome
11
Position
125955796-126063335
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificupper rhombic lipSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
55 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ig | receptor | Surfaceome | No | Yes | No | Yes | No |
| netrinr | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| activating_cofactor | receptor_regulator | CellChatDB | Yes | No | No | Yes | No |
| receptor_regulator | receptor_regulator | OmniPath | Yes | No | No | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CAD15 | P55291 | CDON | Q4KMG0 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:12634428HPRD:12634428 |
| CDON | Q4KMG0 | ABL1 | P00519 | Yes | Yes | No | Lit-BM-17SIGNOR | Lit-BM-17:19470755SIGNOR:19470755 |
| CADH2 | P19022 | CDON | Q4KMG0 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:20160094HPRD:12634428 |
| CDON | Q4KMG0 | JIP4 | O60271 | Yes | Yes | No | SIGNOR | SIGNOR:17074887SIGNOR:18678706 |
| CDON | Q4KMG0 | MK14 | Q16539 | Yes | Yes | No | SIGNOR | SIGNOR:18678706 |
| CDON | Q4KMG0 | BNIP2 | Q12982 | Yes | Yes | No | SIGNOR | SIGNOR:18678706 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDON/SPAG9 | CDONSPAG9 | O60271Q4KMG0 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C21 | |
| PTCH2_CDON_transmembrane_receptor | CDONPTCH2 | Q4KMG0Q9Y6C5 | 1:1 | CellPhoneDB | CellPhoneDB:PTCH2_CDON_transmembrane_receptor | |
| CDONDHH | O43323Q4KMG0 | 3:3 | PDB | PDB:3n1q | ||
| CDONDCBLD1TNFSF8 | P32971Q4KMG0Q8N8Z6 | 0:0:0 | hu.MAP2 | |||
| CDONIHH | Q14623Q4KMG0 | 2:2 | PDB | PDB:3n1f |
Sequence, Structure & Domains
Sequences
Length
1,287
Mass
139,147
Sequence
MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPRET
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q4KMG0-1; Sequence=Displayed; Name=2; IsoId=Q4KMG0-2; Sequence=VSP_018201
Alternative Sequence
1212..1234; Missing (in isoform 2)
3D Structural Models
Helix
852..854; 874..876
Beta Strand
831..837; 839..841; 843..848; 861..868; 878..883; 887..891; 899..908; 919..922
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
537..546; Basic and acidic residues
Domain (FT)
29..114; Ig-like C2-type 1; 120..204; Ig-like C2-type 2; 225..303; Ig-like C2-type 3; 310..396; Ig-like C2-type 4; 405..516; Ig-like C2-type 5; 579..677; Fibronectin type-III 1; 723..821; Fibronectin type-III 2; 826..926; Fibronectin type-III 3
Region
531..553; Disordered; 933..955; Disordered; 1268..1287; Disordered