Protein detail

T4S20

Transmembrane 4 L6 family member 20

Entry name
T4S20
UniProt ID
Q53R12
EVMP confidence score
0.28
Supporting publications (n)
1
Transmembrane count
4
Protein classification
Disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Transmembrane 4 L6 family member 20
Protein Class (5)
Disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (4)
  • Disease related genes
  • Predicted intracellular proteins
  • Transporters:Accessory Factors Involved in Transport
  • Potential drug targets
Transmembrane
15..35; Helical; 45..65; Helical; 84..104; Helical; 186..206; Helical
Transmembrane Count
4
Ensembl
ENSG00000168955
Entrez Gene Symbol
TM4SF20
Gene Synonym (2)
FLJ22800TCCE518
Gene Description
Transmembrane 4 L six family member 20
Chromosome
2
Position
227362038-227381995
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificAdipocytesBlood Cell Specificmemory CD8 T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function (4)
  • Disease related genes
  • Predicted intracellular proteins
  • Transporters:Accessory Factors Involved in Transport
  • Potential drug targets
Cellular Component (4)
Molecular Function
GO:0005515 protein binding
Biological Process (3)
Canonical Pathways (3)
  • M273 Pid epha2 fwd pathway
  • M268 Pid s1p s1p2 pathway
  • M76 Pid p38 alpha beta pathway
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence14

Ligand-Receptor Signaling (11)

11 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
cell_surfacecell_surfaceSurfaceome
cell_surfacecell_surfaceOmniPath
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CD74HSDL1TM4SF20P04233Q3SXM5Q53R120:0:0hu.MAP
CD74TM4SF20P04233Q53R120:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry113929045938225453394435443279541438731868337095102619608537686366307605384121688430451371
Sequence, Structure & Domains

Sequences

Length
229
Mass
25,075
Sequence
MTCCEGWTSCNGFSLLVLLLLGVVLNAIPLIVSLVEEDQFSQNPISCFEWWFPGIIGAGLMAIPATTMSLTARKRACCNNRTGMFLSSLFSVITVIGALYCMLISIQALLKGPLMCNSPSNSNANCEFSLKNISDIHPESFNLQWFFNDSCAPPTGFNKPTSNDTMASGWRASSFHFDSEENKHRLIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSKRRSQIV

Domain & Motif Annotations

Domain (CC)
The first transmembrane helix plays a critical role for the insertion orientation in the endoplasmic reticulum membrane.
Protein Families
L6 tetraspanin family
Sequence Similarities
Belongs to the L6 tetraspanin family.
Clinical Relevance
Disease Involvement
Autism spectrum disorder
Related Diseases
Autism spectrum disorder
Antibody (3)
HPA051838HPA063184HPA065531
Supporting Publications1
PMIDTitleRelated sentences
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No related sentences available