Protein detail

NTCP5

Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5)

Entry name NTCP5	UniProt ID Q5PT55	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 9	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

143..163; Helical; 175..195; Helical; 207..227; Helical; 232..252; Helical; 271..291; Helical; 309..329; Helical; 334..354; Helical; 368..388; Helical; 398..418; Helical

Transmembrane Count

Ensembl

ENSG00000253598

Entrez Gene Symbol

SLC10A5

Gene Description

Solute carrier family 10 member 5

Chromosome

Position

81693631-81695058

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificastrocyte

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0008508 bile acid:sodium symporter activity

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence16

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
slc10	transporter	Surfaceome	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	5	39290459 38731868 30550287 40098346 31320591

Sequence, Structure & Domains5

Sequences

Length

438

Mass

48,871

Sequence

MIRKLFIVLLLLLVTIEEARMSSLSFLNIEKTEILFFTKTEETILVSSSYENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINLVTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKDSLLQAPMHIDRNILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAFGVVMTCTCPGGGGGYLFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIYSRILGLSGTFHIPVSKIVSTLLFILVPVSIGIVIKHRIPEKASFLERIIRPLSFILMFVGIYLTFTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVCKTVAIESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIILVYKAKKRCIFFLQDKRKRNFLI

Domain & Motif Annotations

Protein Families

Bile acid:sodium symporter (BASS) (TC 2.A.28) family

Sequence Similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.

Clinical Relevance1

Antibody

HPA025966

Supporting Publications1

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available