Protein detail

NTCP5

Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5)

Entry name NTCP5	UniProt ID Q5PT55	EVMP score 0.50
Frequency 1	Transmembrane count 9	Protein classification Predicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

143..163; Helical; 175..195; Helical; 207..227; Helical; 232..252; Helical; 271..291; Helical; 309..329; Helical; 334..354; Helical; 368..388; Helical; 398..418; Helical

Transmembrane Count

Ensembl

ENSG00000253598

Entrez Gene Symbol

SLC10A5

Gene Description

Solute carrier family 10 member 5

Chromosome

Position

81693631-81695058

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0008508 bile acid:sodium symporter activity

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	5	39290459 38731868 30550287 40098346 31320591

Sequence, Structure & Domains

Sequences

Length

438

Mass

48,871

Sequence

MIRKLFIVLLLLLVTIEEARMSSLSFLNIEKTEILFFTKTEETILVSSSYENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINLVTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKDSLLQAPMHIDRNILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAFGVVMTCTCPGGGGGYLFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIYSRILGLSGTFHIPVSKIVSTLLFILVPVSIGIVIKHRIPEKASFLERIIRPLSFILMFVGIYLTFTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVCKTVAIESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIILVYKAKKRCIFFLQDKRKRNFLI

3D Structural Models

Domain & Motif Annotations

Protein Families

Bile acid:sodium symporter (BASS) (TC 2.A.28) family

Sequence Similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.

Clinical Relevance

Antibody

HPA025966