Protein detail

GP107

Protein GPR107 (Lung seven transmembrane receptor 1)

Entry name GP107	UniProt ID Q5VW38	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count 7	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein GPR107 (Lung seven transmembrane receptor 1)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters

Transmembrane

264..284; Helical; Name=1; 294..314; Helical; Name=2; 338..358; Helical; Name=3; 369..389; Helical; Name=4; 403..423; Helical; Name=5; 499..519; Helical; Name=6; 525..544; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000148358

Entrez Gene Symbol

GPR107

Gene Synonym (4)

FLJ20998KIAA1624LUSTR1RP11-88G17

Gene Description

G protein-coupled receptor 107

Chromosome

Position

130053426-130140169

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificeccentric medium spiny neuron

Function & Pathway5

Protein Function

Transporters

Cellular Component (6)

Molecular Function

GO:0032050 clathrin heavy chain binding

Biological Process (3)

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence36

Ligand-Receptor Signaling (34)

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
seven_tm_other	receptor	HPMR	No	Yes	No	Yes	No
progestin_and_adiponectin_membrane_seven_tm_other	receptor	HPMR	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
other_gpcrs	receptor	GPCRdb	No	Yes	No	Yes	No
other_gpcrs_orphan	receptor	GPCRdb	No	Yes	No	Yes	No
other_gpcrs_orphan_other_gpcr_orphans	receptor	GPCRdb	No	Yes	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	COX20 GPR107 UQCC4	Q4G0I0 Q5RI15 Q5VW38	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	38113368 33592500 41307968 27821849 32230970

Sequence, Structure & Domains9

Sequences

Length

600

Mass

66,990

Sequence

MAALAPVGSPASRGPRLAAGLRLLPMLGLLQLLAEPGLGRVHHLALKDDVRHKVHLNTFGFFKDGYMVVNVSSLSLNEPEDKDVTIGFSLDRTKNDGFSSYLDEDVNYCILKKQSVSVTLLILDISRSEVRVKSPPEAGTQLPKIIFSRDEKVLGQSQEPNVNPASAGNQTQKTQDGGKSKRSTVDSKAMGEKSFSVHNNGGAVSFQFFFNISTDDQEGLYSLYFHKCLGKELPSDKFTFSLDIEITEKNPDSYLSAGEIPLPKLYISMAFFFFLSGTIWIHILRKRRNDVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLLKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKDSLFLVDLLCCGAILFPVVWSIRHLQEASATDGKGDSMGPLQQRANLRAGSRIESHHFAQADLELLASSCPPASVSQRAGITAAINLAKLKLFRHYYVLIVCYIYFTRIIAFLLKLAVPFQWKWLYQLLDETATLVFFVLTGYKFRPASDNPYLQLSQEEEDLEMESVVTTSGVMESMKKVKKVTNGSVEPQGEWEGAV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VW38-1; Sequence=Displayed; Name=2; IsoId=Q5VW38-2; Sequence=VSP_014436; Name=3; IsoId=Q5VW38-3; Sequence=VSP_014434, VSP_014435

Alternative Sequence

298..300; MAA -> GFH (in isoform 3); 301..600; Missing (in isoform 3); 436..483; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

157..175; Polar residues; 176..185; Basic and acidic residues

Region

157..185; Disordered

Protein Families

LU7TM family

Sequence Similarities

Belongs to the LU7TM family.

Clinical Relevance1

Antibody

HPA031704

Supporting Publications6

PMID	Title	Abstract
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available