Protein detail

GP107

Protein GPR107 (Lung seven transmembrane receptor 1)

Entry name GP107	UniProt ID Q5VW38	EVMP score 0.38
Frequency 6	Transmembrane count 7	Protein classification Predicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein GPR107 (Lung seven transmembrane receptor 1)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters

Transmembrane

264..284; Helical; Name=1; 294..314; Helical; Name=2; 338..358; Helical; Name=3; 369..389; Helical; Name=4; 403..423; Helical; Name=5; 499..519; Helical; Name=6; 525..544; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000148358

Entrez Gene Symbol

GPR107

Gene Synonym

FLJ20998KIAA1624LUSTR1RP11-88G17

Gene Description

G protein-coupled receptor 107

Chromosome

Position

130053426-130140169

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificeccentric medium spiny neuron

Function & Pathway

Protein Function

Transporters

Cellular Component

Molecular Function

GO:0032050 clathrin heavy chain binding

Biological Process

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	COX20 GPR107 UQCC4	Q4G0I0 Q5RI15 Q5VW38	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	38113368 33592500 41307968 27821849 32230970

Sequence, Structure & Domains

Sequences

Length

600

Mass

66,990

Sequence

MAALAPVGSPASRGPRLAAGLRLLPMLGLLQLLAEPGLGRVHHLALKDDVRHKVHLNTFGFFKDGYMVVNVSSLSLNEPEDKDVTIGFSLDRTKNDGFSSYLDEDVNYCILKKQSVSVTLLILDISRSEVRVKSPPEAGTQLPKIIFSRDEKVLGQSQEPNVNPASAGNQTQKTQDGGKSKRSTVDSKAMGEKSFSVHNNGGAVSFQFFFNISTDDQEGLYSLYFHKCLGKELPSDKFTFSLDIEITEKNPDSYLSAGEIPLPKLYISMAFFFFLSGTIWIHILRKRRNDVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLLKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKDSLFLVDLLCCGAILFPVVWSIRHLQEASATDGKGDSMGPLQQRANLRAGSRIESHHFAQADLELLASSCPPASVSQRAGITAAINLAKLKLFRHYYVLIVCYIYFTRIIAFLLKLAVPFQWKWLYQLLDETATLVFFVLTGYKFRPASDNPYLQLSQEEEDLEMESVVTTSGVMESMKKVKKVTNGSVEPQGEWEGAV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VW38-1; Sequence=Displayed; Name=2; IsoId=Q5VW38-2; Sequence=VSP_014436; Name=3; IsoId=Q5VW38-3; Sequence=VSP_014434, VSP_014435

Alternative Sequence

298..300; MAA -> GFH (in isoform 3); 301..600; Missing (in isoform 3); 436..483; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

157..175; Polar residues; 176..185; Basic and acidic residues

Region

157..185; Disordered

Protein Families

LU7TM family

Sequence Similarities

Belongs to the LU7TM family.

Clinical Relevance

Antibody

HPA031704