Protein detail

GP107

Protein GPR107 (Lung seven transmembrane receptor 1)

Entry name GP107	UniProt ID Q5VW38	EVMP score 0.38
Frequency 6	Transmembrane count 7	Protein classification Predicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein GPR107 (Lung seven transmembrane receptor 1)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters

Transmembrane

264..284; Helical; Name=1; 294..314; Helical; Name=2; 338..358; Helical; Name=3; 369..389; Helical; Name=4; 403..423; Helical; Name=5; 499..519; Helical; Name=6; 525..544; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000148358

Entrez Gene Symbol

GPR107

Gene Synonym

FLJ20998KIAA1624LUSTR1RP11-88G17

Gene Description

G protein-coupled receptor 107

Chromosome

Position

130053426-130140169

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificeccentric medium spiny neuron

Function & Pathway

Protein Function

Transporters

Cellular Component

Molecular Function

GO:0032050 clathrin heavy chain binding

Biological Process

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No

Page 3 of 4Previous Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	COX20 GPR107 UQCC4	Q4G0I0 Q5RI15 Q5VW38	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	38113368 33592500 41307968 27821849 32230970

Sequence, Structure & Domains

Sequences

Length

600

Mass

66,990

Sequence

MAALAPVGSPASRGPRLAAGLRLLPMLGLLQLLAEPGLGRVHHLALKDDVRHKVHLNTFGFFKDGYMVVNVSSLSLNEPEDKDVTIGFSLDRTKNDGFSSYLDEDVNYCILKKQSVSVTLLILDISRSEVRVKSPPEAGTQLPKIIFSRDEKVLGQSQEPNVNPASAGNQTQKTQDGGKSKRSTVDSKAMGEKSFSVHNNGGAVSFQFFFNISTDDQEGLYSLYFHKCLGKELPSDKFTFSLDIEITEKNPDSYLSAGEIPLPKLYISMAFFFFLSGTIWIHILRKRRNDVFKIHWLMAALPFTKSLSLVFHAIDYHYISSQGFPIEGWAVVYYITHLLKGALLFITIALIGTGWAFIKHILSDKDKKIFMIVIPLQVLANVAYIIIESTEEGTTEYGLWKDSLFLVDLLCCGAILFPVVWSIRHLQEASATDGKGDSMGPLQQRANLRAGSRIESHHFAQADLELLASSCPPASVSQRAGITAAINLAKLKLFRHYYVLIVCYIYFTRIIAFLLKLAVPFQWKWLYQLLDETATLVFFVLTGYKFRPASDNPYLQLSQEEEDLEMESVVTTSGVMESMKKVKKVTNGSVEPQGEWEGAV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5VW38-1; Sequence=Displayed; Name=2; IsoId=Q5VW38-2; Sequence=VSP_014436; Name=3; IsoId=Q5VW38-3; Sequence=VSP_014434, VSP_014435

Alternative Sequence

298..300; MAA -> GFH (in isoform 3); 301..600; Missing (in isoform 3); 436..483; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

157..175; Polar residues; 176..185; Basic and acidic residues

Region

157..185; Disordered

Protein Families

LU7TM family

Sequence Similarities

Belongs to the LU7TM family.

Clinical Relevance

Antibody

HPA031704