Protein detail

CBPZ

Carboxypeptidase Z (CPZ) (EC 3.4.17.-)

Entry name CBPZ	UniProt ID Q66K79	EVMP confidence score 0.60
Supporting publications (n) 14	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Carboxypeptidase Z (CPZ) (EC 3.4.17.-)

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins
Predicted intracellular proteins

Ensembl

ENSG00000109625

Entrez Gene Symbol

CPZ

Supporting publications (n)

EVMP confidence score

0.60

Function & Pathway5

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins
Predicted intracellular proteins

Cellular Component

GO:0005615 extracellular space

Molecular Function (2)

Biological Process (3)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence19

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted_peptidase	secreted_peptidase	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
receptor	receptor	scConnect	No	Yes	Yes	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingELISA	4	32795414 38731868 26801919 40784529

Sequence, Structure & Domains9

Sequences

Length

652

Mass

73,655

Sequence

MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q66K79-1; Sequence=Displayed; Name=2; IsoId=Q66K79-2; Sequence=VSP_020983; Name=3; IsoId=Q66K79-3; Sequence=VSP_040356

Alternative Sequence

1..137; Missing (in isoform 3); 30..40; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

27..160; FZ; 186..502; Peptidase M14

Region

595..629; Disordered

Protein Families

Peptidase M14 family

Sequence Similarities

Belongs to the peptidase M14 family.

Supporting Publications14

PMID	Title	Abstract
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39558134	Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.	No abstract available
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available

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