Protein detail
CBPZ
Carboxypeptidase Z (CPZ) (EC 3.4.17.-)
Entry name CBPZ | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 14 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Carboxypeptidase Z (CPZ) (EC 3.4.17.-)
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted secreted proteins
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
14
EVMP confidence score
0.60
Function & Pathway5
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| m14_carboxypeptidase | secreted_peptidase | OmniPath | No | No | Yes | No | No |
| carboxypeptidase | secreted_peptidase | OmniPath | No | No | Yes | No | No |
| secreted_enzyme | secreted_enzyme | OmniPath | Yes | No | Yes | No | No |
| ecm | ecm | MatrixDB | Yes | No | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| ecm | ecm | CellCellInteractions | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
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Sequence, Structure & Domains9
Sequences
Length
652
Mass
73,655
Sequence
MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q66K79-1; Sequence=Displayed; Name=2; IsoId=Q66K79-2; Sequence=VSP_020983; Name=3; IsoId=Q66K79-3; Sequence=VSP_040356
Alternative Sequence
1..137; Missing (in isoform 3); 30..40; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
27..160; FZ; 186..502; Peptidase M14
Region
595..629; Disordered
Protein Families
Peptidase M14 family
Sequence Similarities
Belongs to the peptidase M14 family.
Supporting Publications14
| PMID | Title | Abstract |
|---|---|---|
| 35611462 | Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 39558134 | Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis. | No abstract available |
| 40748658 | Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures. | No abstract available |
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