Protein detail

FCRL6

Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)

Protein symbol FCRL6	UniProt ID Q6DN72	EVMP score 0.25
Frequency 3	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)

Protein Function

Predicted intracellular proteins

Transmembrane

308..328; Helical

Transmembrane Count

Ensembl

ENSG00000181036

Entrez Gene Symbol

FCRL6

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	4	40928027 38731868 28963552 38321535

Sequence, Structure & Domains

Sequences

Length

434

Mass

47,748

Sequence

MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=FCRL6v1; IsoId=Q6DN72-1; Sequence=Displayed; Name=2; IsoId=Q6DN72-2; Sequence=VSP_023565, VSP_023568, VSP_023570; Name=3; Synonyms=FCRL6v4; IsoId=Q6DN72-3; Sequence=VSP_023567, VSP_023569; Name=4; IsoId=Q6DN72-4; Sequence=VSP_023566, VSP_023568, VSP_023570

Alternative Sequence

1; M -> MLPSLGPM (in isoform 2); 105..199; Missing (in isoform 4); 383..397; ARSAEFTVGRKDSSI -> GQFYHLCGGEMPAAQ (in isoform 3); 394..406; DSSIICAEVRCLQ -> FYHLCGGEMPAAQ (in isoform 2 and isoform 4); 398..434; Missing (in isoform 3); 407..434; Missing (in isoform 2 and isoform 4)

3D Structural Models

Domain & Motif Annotations

Motif

369..374; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.

Domain (FT)

20..95; Ig-like C2-type 1; 111..197; Ig-like C2-type 2; 207..293; Ig-like C2-type 3

Clinical Relevance