Protein detail

FCRL6

Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)

Entry name FCRL6	UniProt ID Q6DN72	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)

Protein Function

Predicted intracellular proteins

Transmembrane

308..328; Helical

Transmembrane Count

Ensembl

ENSG00000181036

Entrez Gene Symbol

FCRL6

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (5)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence33

Ligand-Receptor Signaling (32)

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

Page 4 of 4Previous

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	4	40928027 38731868 28963552 38321535

Sequence, Structure & Domains8

Sequences

Length

434

Mass

47,748

Sequence

MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=FCRL6v1; IsoId=Q6DN72-1; Sequence=Displayed; Name=2; IsoId=Q6DN72-2; Sequence=VSP_023565, VSP_023568, VSP_023570; Name=3; Synonyms=FCRL6v4; IsoId=Q6DN72-3; Sequence=VSP_023567, VSP_023569; Name=4; IsoId=Q6DN72-4; Sequence=VSP_023566, VSP_023568, VSP_023570

Alternative Sequence

1; M -> MLPSLGPM (in isoform 2); 105..199; Missing (in isoform 4); 383..397; ARSAEFTVGRKDSSI -> GQFYHLCGGEMPAAQ (in isoform 3); 394..406; DSSIICAEVRCLQ -> FYHLCGGEMPAAQ (in isoform 2 and isoform 4); 398..434; Missing (in isoform 3); 407..434; Missing (in isoform 2 and isoform 4)

Domain & Motif Annotations

Motif

369..374; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.

Domain (FT)

20..95; Ig-like C2-type 1; 111..197; Ig-like C2-type 2; 207..293; Ig-like C2-type 3

Supporting Publications3

PMID	Title	Abstract
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available