Protein detail

CNNM4

Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)

Entry name CNNM4	UniProt ID Q6P4Q7	EVMP confidence score 0.50
Supporting publications (n) 6	Transmembrane count 3	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Nervous system diseases:Eye disease
Potential drug targets

Transmembrane

179..199; Helical; 265..285; Helical; 294..316; Helical

Transmembrane Count

Ensembl

ENSG00000158158

Entrez Gene Symbol

CNNM4

Gene Synonym (2)

ACDP4KIAA1592

Gene Description

Cyclin and CBS domain divalent metal cation transport mediator 4

Chromosome

Position

96760902-96811874

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificAstrocytes

Function & Pathway5

Protein Function (4)

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Nervous system diseases:Eye disease
Potential drug targets

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence22

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CNNM4	Q6P4Q7	9	PDB	PDB:6g52PDB:6rs2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	38113368 33936570 32854315 40730843 36146834 31805958 38207106

Sequence, Structure & Domains9

Sequences

Length

775

Mass

86,607

Sequence

MAPVGGGGRPVGGPARGRLLLAAPVLLVLLWALGARGQGSPQQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSRGNTSGVLVVLTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P4Q7-1; Sequence=Displayed; Name=2; IsoId=Q6P4Q7-2; Sequence=VSP_054271, VSP_054272

Alternative Sequence

1..513; Missing (in isoform 2); 711..775; ITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI -> PQSWPCFSRPGDRVCLPAPPSMNSSLPHADHSAAVPERAAGFSHGEQPSVSHRRVHHPHGELGREV (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

178..358; CNNM transmembrane; 377..438; CBS 1; 445..511; CBS 2

Protein Families

ACDP family

Sequence Similarities

Belongs to the ACDP family.

Clinical Relevance5

Disease Involvement (3)

Amelogenesis imperfectaCone-rod dystrophyDisease variant

Antibody

HPA017732

Interaction Protein (2)

ENSG00000112245ENSG00000184007

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications6

PMID	Title	Abstract
33936570	Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available