Protein detail

CNNM4

Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)

Protein symbol CNNM4	UniProt ID Q6P4Q7	EVMP score 0.50
Frequency 6	Transmembrane count 3	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)

Protein Class

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Nervous system diseases:Eye disease
Potential drug targets

Transmembrane

179..199; Helical; 265..285; Helical; 294..316; Helical

Transmembrane Count

Ensembl

ENSG00000158158

Entrez Gene Symbol

CNNM4

Gene Synonym

ACDP4KIAA1592

Gene Description

Cyclin and CBS domain divalent metal cation transport mediator 4

Chromosome

Position

96760902-96811874

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAstrocytes

Function & Pathway

Protein Function

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Nervous system diseases:Eye disease
Potential drug targets

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CNNM4	Q6P4Q7	9	PDB	PDB:6g52PDB:6rs2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	38113368 33936570 32854315 40730843 36146834 31805958 38207106

Sequence, Structure & Domains

Sequences

Length

775

Mass

86,607

Sequence

MAPVGGGGRPVGGPARGRLLLAAPVLLVLLWALGARGQGSPQQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSRGNTSGVLVVLTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P4Q7-1; Sequence=Displayed; Name=2; IsoId=Q6P4Q7-2; Sequence=VSP_054271, VSP_054272

Alternative Sequence

1..513; Missing (in isoform 2); 711..775; ITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI -> PQSWPCFSRPGDRVCLPAPPSMNSSLPHADHSAAVPERAAGFSHGEQPSVSHRRVHHPHGELGREV (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

178..358; CNNM transmembrane; 377..438; CBS 1; 445..511; CBS 2

Protein Families

ACDP family

Sequence Similarities

Belongs to the ACDP family.

Clinical Relevance

Disease Involvement

Amelogenesis imperfectaCone-rod dystrophyDisease variant

Antibody

HPA017732

Interaction Protein

ENSG00000112245ENSG00000184007

Interaction Count

Interaction Dataset

biogrid_bioplex