Protein detail

CNNM4

Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)

Protein symbol CNNM4	UniProt ID Q6P4Q7	EVMP score 0.50
Frequency 6	Transmembrane count 3	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)

Protein Class

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Nervous system diseases:Eye disease
Potential drug targets

Transmembrane

179..199; Helical; 265..285; Helical; 294..316; Helical

Transmembrane Count

Ensembl

ENSG00000158158

Entrez Gene Symbol

CNNM4

Gene Synonym

ACDP4KIAA1592

Gene Description

Cyclin and CBS domain divalent metal cation transport mediator 4

Chromosome

Position

96760902-96811874

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAstrocytes

Function & Pathway

Protein Function

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Nervous system diseases:Eye disease
Potential drug targets

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
peripheral	peripheral	UniProt_topology	No	No	No	Yes	No
peripheral	peripheral	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CNNM4	Q6P4Q7	9	PDB	PDB:6g52PDB:6rs2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	38113368 33936570 32854315 40730843 36146834 31805958 38207106

Sequence, Structure & Domains

Sequences

Length

775

Mass

86,607

Sequence

MAPVGGGGRPVGGPARGRLLLAAPVLLVLLWALGARGQGSPQQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSRGNTSGVLVVLTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P4Q7-1; Sequence=Displayed; Name=2; IsoId=Q6P4Q7-2; Sequence=VSP_054271, VSP_054272

Alternative Sequence

1..513; Missing (in isoform 2); 711..775; ITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI -> PQSWPCFSRPGDRVCLPAPPSMNSSLPHADHSAAVPERAAGFSHGEQPSVSHRRVHHPHGELGREV (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

178..358; CNNM transmembrane; 377..438; CBS 1; 445..511; CBS 2

Protein Families

ACDP family

Sequence Similarities

Belongs to the ACDP family.

Clinical Relevance

Disease Involvement

Amelogenesis imperfectaCone-rod dystrophyDisease variant

Antibody

HPA017732

Interaction Protein

ENSG00000112245ENSG00000184007

Interaction Count

Interaction Dataset

biogrid_bioplex