Protein detail

LRC8B

Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)

Protein symbol LRC8B	UniProt ID Q6P9F7	EVMP score 0.25
Frequency 2	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

Basic Information

Protein Names

Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

26..46; Helical; Name=1; 120..140; Helical; Name=2; 262..282; Helical; Name=3; 308..328; Helical; Name=4

Transmembrane Count

Ensembl

ENSG00000197147

Entrez Gene Symbol

LRRC8B

Gene Synonym

KIAA0231TA-LRRP

Gene Description

Leucine rich repeat containing 8 VRAC subunit B

Chromosome

Position

89524829-89597861

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificendometrium 1Brain Regional SpecificcerebellumCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificfibroblast

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
volume_regulated_anion	ion_channel	HGNC	No	Yes	No	No	No
ion_channel	ion_channel	HGNC	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	36736734 31382537 27821849 38716512 34815502

Sequence, Structure & Domains

Sequences

Length

803

Mass

92,390

Sequence

MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC

3D Structural Models

Domain & Motif Annotations

Repeat

464..486; LRR 1; 488..509; LRR 2; 511..532; LRR 3; 539..559; LRR 4; 562..582; LRR 5; 586..607; LRR 6; 609..630; LRR 7; 634..655; LRR 8; 657..678; LRR 9; 680..701; LRR 10; 703..724; LRR 11; 726..747; LRR 12; 749..771; LRR 13

Domain (CC)

The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

Protein Families

LRRC8 family

Sequence Similarities

Belongs to the LRRC8 family.

Clinical Relevance

Antibody

HPA017950

Interaction Protein

ENSG00000136802

Interaction Count

Interaction Dataset

intact_biogrid