Protein detail

LRC8B

Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)

Entry name LRC8B	UniProt ID Q6P9F7	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

26..46; Helical; Name=1; 120..140; Helical; Name=2; 262..282; Helical; Name=3; 308..328; Helical; Name=4

Transmembrane Count

Ensembl

ENSG00000197147

Entrez Gene Symbol

LRRC8B

Gene Synonym (2)

KIAA0231TA-LRRP

Gene Description

Leucine rich repeat containing 8 VRAC subunit B

Chromosome

Position

89524829-89597861

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue Specificendometrium 1Brain Regional SpecificcerebellumCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificfibroblast

Function & Pathway6

Protein Function

Transporters:Transporter channels and pores

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Reactome (2)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence18

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	36736734 31382537 27821849 38716512 34815502

Sequence, Structure & Domains7

Sequences

Length

803

Mass

92,390

Sequence

MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC

Domain & Motif Annotations

Repeat

464..486; LRR 1; 488..509; LRR 2; 511..532; LRR 3; 539..559; LRR 4; 562..582; LRR 5; 586..607; LRR 6; 609..630; LRR 7; 634..655; LRR 8; 657..678; LRR 9; 680..701; LRR 10; 703..724; LRR 11; 726..747; LRR 12; 749..771; LRR 13

Domain (CC)

The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

Protein Families

LRRC8 family

Sequence Similarities

Belongs to the LRRC8 family.

Clinical Relevance4

Antibody

HPA017950

Interaction Protein

ENSG00000136802

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
37403840	Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma.	No abstract available
38731977	Exosomes Secreted by Wharton's Jelly-Derived Mesenchymal Stem Cells Promote the Ability of Cell Proliferation and Migration for Keratinocyte.	No abstract available