Protein detail
LRC8B
Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)
Protein symbol LRC8B | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
26..46; Helical; Name=1; 120..140; Helical; Name=2; 262..282; Helical; Name=3; 308..328; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0231TA-LRRP
Gene Description
Leucine rich repeat containing 8 VRAC subunit B
Chromosome
1
Position
89524829-89597861
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificendometrium 1Brain Regional SpecificcerebellumCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificfibroblast
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
803
Mass
92,390
Sequence
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC
3D Structural Models
Domain & Motif Annotations
Repeat
464..486; LRR 1; 488..509; LRR 2; 511..532; LRR 3; 539..559; LRR 4; 562..582; LRR 5; 586..607; LRR 6; 609..630; LRR 7; 634..655; LRR 8; 657..678; LRR 9; 680..701; LRR 10; 703..724; LRR 11; 726..747; LRR 12; 749..771; LRR 13
Domain (CC)
The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.
Protein Families
LRRC8 family
Sequence Similarities
Belongs to the LRRC8 family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000136802
Interaction Count
1
Interaction Dataset
intact_biogrid