Protein detail
IYD1
Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
Protein symbol IYD1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
Protein Class
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins
Protein Function
- ENZYME proteins:Oxidoreductases
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- Potential drug targets
- Enzymes
- Disease related genes
Transmembrane
1..21; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C6orf71DEHAL1dJ422F24.1
Gene Description
Iodotyrosine deiodinase
Chromosome
6
Position
150368892-150405969
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- ENZYME proteins:Oxidoreductases
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryR Sequencing | 1 | 39341061 |
Sequence, Structure & Domains
Sequences
Length
289
Mass
33,360
Sequence
MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6PHW0-1; Sequence=Displayed; Name=3; Synonyms=E; IsoId=Q6PHW0-3; Sequence=VSP_017809, VSP_017810; Name=4; Synonyms=B; IsoId=Q6PHW0-4; Sequence=VSP_017805; Name=5; Synonyms=C; IsoId=Q6PHW0-5; Sequence=VSP_017806, VSP_017813; Name=6; Synonyms=D; IsoId=Q6PHW0-6; Sequence=VSP_017807, VSP_017812; Name=7; Synonyms=F; IsoId=Q6PHW0-7; Sequence=VSP_017802, VSP_017803, VSP_017809, VSP_017810
Alternative Sequence
1..55; Missing (in isoform 7); 56..61; QAEEDA -> MKEADV (in isoform 7); 230..289; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGCPECRSGDCHYHSSQLWPSTEGAPGPPRT (in isoform 4); 230..284; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQ -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGRPGASAAGSLFHFAIEFAAP (in isoform 5); 230..270; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSK -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGRPGFYC (in isoform 6); 230..248; NAGLVTVTTTPLNCGPRLR -> VFGKIILKELALISFLNL (in isoform 3 and isoform 7); 249..289; Missing (in isoform 3 and isoform 7); 271..289; Missing (in isoform 6); 285..289; Missing (in isoform 5)
3D Structural Models
Helix
83..98; 113..123; 129..131; 143..162; 167..173; 174..176; 184..187; 213..230; 244..250; 282..284
Beta Strand
73..75; 77..79; 135..140; 189..201; 207..209; 257..266; 273..275; 286..289
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
29..58; Basic and acidic residues; 59..69; Acidic residues
Region
29..69; Disordered
Protein Families
Nitroreductase family
Sequence Similarities
Belongs to the nitroreductase family.
Clinical Relevance
Disease Involvement
Congenital hypothyroidismDisease variant
Antibody