Protein detail

IYD1

Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)

Entry name IYD1	UniProt ID Q6PHW0	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)

Protein Class (5)

Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins

Protein Function (5)

ENZYME proteins:Oxidoreductases
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Potential drug targets
Enzymes
Disease related genes

Transmembrane

1..21; Helical

Transmembrane Count

Ensembl

ENSG00000009765

Entrez Gene Symbol

IYD

Gene Synonym (3)

C6orf71DEHAL1dJ422F24.1

Gene Description

Iodotyrosine deiodinase

Chromosome

Position

150368892-150405969

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway7

Protein Function (5)

ENZYME proteins:Oxidoreductases
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Potential drug targets
Enzymes
Disease related genes

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04918 Thyroid hormone synthesis

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence24

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IYD	Q6PHW0	2	PDB	PDB:4ttbPDB:5yakPDB:4ttc

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryR Sequencing	1	39341061

Sequence, Structure & Domains12

Sequences

Length

289

Mass

33,360

Sequence

MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6PHW0-1; Sequence=Displayed; Name=3; Synonyms=E; IsoId=Q6PHW0-3; Sequence=VSP_017809, VSP_017810; Name=4; Synonyms=B; IsoId=Q6PHW0-4; Sequence=VSP_017805; Name=5; Synonyms=C; IsoId=Q6PHW0-5; Sequence=VSP_017806, VSP_017813; Name=6; Synonyms=D; IsoId=Q6PHW0-6; Sequence=VSP_017807, VSP_017812; Name=7; Synonyms=F; IsoId=Q6PHW0-7; Sequence=VSP_017802, VSP_017803, VSP_017809, VSP_017810

Alternative Sequence

1..55; Missing (in isoform 7); 56..61; QAEEDA -> MKEADV (in isoform 7); 230..289; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGCPECRSGDCHYHSSQLWPSTEGAPGPPRT (in isoform 4); 230..284; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQ -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGRPGASAAGSLFHFAIEFAAP (in isoform 5); 230..270; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSK -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGRPGFYC (in isoform 6); 230..248; NAGLVTVTTTPLNCGPRLR -> VFGKIILKELALISFLNL (in isoform 3 and isoform 7); 249..289; Missing (in isoform 3 and isoform 7); 271..289; Missing (in isoform 6); 285..289; Missing (in isoform 5)

3D Structural Models

Helix

83..98; 113..123; 129..131; 143..162; 167..173; 174..176; 184..187; 213..230; 244..250; 282..284

Beta Strand

73..75; 77..79; 135..140; 189..201; 207..209; 257..266; 273..275; 286..289

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

29..58; Basic and acidic residues; 59..69; Acidic residues

Region

29..69; Disordered

Protein Families

Nitroreductase family

Sequence Similarities

Belongs to the nitroreductase family.

Clinical Relevance2

Disease Involvement (2)

Congenital hypothyroidismDisease variant

Antibody

HPA059627

Supporting Publications1

PMID	Title	Abstract
39195200	Analysis of Cytotoxic Granules and Constitutively Produced Extracellular Vesicles from Large Granular Lymphocytic Leukemia Cell Lines.	No abstract available