Protein detail

IYD1

Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)

Entry name IYD1	UniProt ID Q6PHW0	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)

Protein Class

Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins

Protein Function

ENZYME proteins:Oxidoreductases
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Potential drug targets
Enzymes
Disease related genes

Transmembrane

1..21; Helical

Transmembrane Count

Ensembl

ENSG00000009765

Entrez Gene Symbol

IYD

Gene Synonym

C6orf71DEHAL1dJ422F24.1

Gene Description

Iodotyrosine deiodinase

Chromosome

Position

150368892-150405969

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

ENZYME proteins:Oxidoreductases
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Potential drug targets
Enzymes
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04918 Thyroid hormone synthesis

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IYD	Q6PHW0	2	PDB	PDB:4ttbPDB:5yakPDB:4ttc

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryR Sequencing	1	39341061

Sequence, Structure & Domains

Sequences

Length

289

Mass

33,360

Sequence

MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q6PHW0-1; Sequence=Displayed; Name=3; Synonyms=E; IsoId=Q6PHW0-3; Sequence=VSP_017809, VSP_017810; Name=4; Synonyms=B; IsoId=Q6PHW0-4; Sequence=VSP_017805; Name=5; Synonyms=C; IsoId=Q6PHW0-5; Sequence=VSP_017806, VSP_017813; Name=6; Synonyms=D; IsoId=Q6PHW0-6; Sequence=VSP_017807, VSP_017812; Name=7; Synonyms=F; IsoId=Q6PHW0-7; Sequence=VSP_017802, VSP_017803, VSP_017809, VSP_017810

Alternative Sequence

1..55; Missing (in isoform 7); 56..61; QAEEDA -> MKEADV (in isoform 7); 230..289; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGCPECRSGDCHYHSSQLWPSTEGAPGPPRT (in isoform 4); 230..284; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQ -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGRPGASAAGSLFHFAIEFAAP (in isoform 5); 230..270; NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSK -> VNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGRPGFYC (in isoform 6); 230..248; NAGLVTVTTTPLNCGPRLR -> VFGKIILKELALISFLNL (in isoform 3 and isoform 7); 249..289; Missing (in isoform 3 and isoform 7); 271..289; Missing (in isoform 6); 285..289; Missing (in isoform 5)

3D Structural Models

Helix

83..98; 113..123; 129..131; 143..162; 167..173; 174..176; 184..187; 213..230; 244..250; 282..284

Beta Strand

73..75; 77..79; 135..140; 189..201; 207..209; 257..266; 273..275; 286..289

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

29..58; Basic and acidic residues; 59..69; Acidic residues

Region

29..69; Disordered

Protein Families

Nitroreductase family

Sequence Similarities

Belongs to the nitroreductase family.

Clinical Relevance

Disease Involvement

Congenital hypothyroidismDisease variant

Antibody

HPA059627