Protein detail
RHDF2
Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)
Entry name RHDF2 | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count 7 | Protein classification Disease related genesEnzymesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)
Protein Class
Disease related genesEnzymesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Peptidases:Serine-type peptidases
- Enzymes
- Disease related genes
Transmembrane
410..430; Helical; 661..681; Helical; 693..713; Helical; 716..736; Helical; 748..768; Helical; 774..794; Helical; 803..823; Helical
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ22341iRhom2RHBDL5RHBDL6TOCTOCG
Gene Description
Rhomboid 5 homolog 2
Chromosome
17
Position
76470891-76501790
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificBergmann gliaSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Peptidases:Serine-type peptidases
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
856
Mass
96,686
Sequence
MASADKNGGSVSSVSSSRLQSRKPPNLSITIPPPEKETQAPGEQDSMLPEGFQNRRLKKSQPRTWAAHTTACPPSFLPKRKNPAYLKSVSLQEPRSRWQESSEKRPGFRRQASLSQSIRKGAAQWFGVSGDWEGQRQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPKIVDPLARGRAFRHPEEMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLPRRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRVVKRSFAFPSFLEEDVVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGIPHSASPVSPDGVQIPLKEYGRAPVPGPRRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHVIITLLVICTYGIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQIEQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDKSDLGQKRTSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQARSNHTGFLHMDCEIKGRPCCIGTKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLAFAGLFAALVLWLYIYPINWPWIEHLTCFPFTSRFCEKYELDQVLH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PJF5-1; Sequence=Displayed; Name=2; IsoId=Q6PJF5-2; Sequence=VSP_034368
Alternative Sequence
51..79; Missing (in isoform 2)
3D Structural Models
Turn
518..520; 528..530; 553..555; 589..591; 843..850
Helix
373..377; 388..395; 403..422; 463..469; 474..477; 481..495; 513..515; 563..565; 571..573; 613..618; 630..632; 635..640; 656..659; 660..662; 667..688; 690..711; 721..737; 739..741; 745..763; 770..787; 795..824; 832..837
Beta Strand
429..440; 442..454; 457..460; 498..504; 508..511; 521..524; 540..542; 556..558; 578..580; 598..601; 603..606; 608..611; 742..744; 852..854
3D Structure
Electron microscopy (5)
Domain & Motif Annotations
Compositional Bias
94..106; Basic and acidic residues
Region
1..115; Disordered; 165..184; Disordered; 191..271; Involved in interaction with FRMD8; 531..553; Disordered
Protein Families
Peptidase S54 family
Sequence Similarities
Belongs to the peptidase S54 family.
Clinical Relevance
Disease Involvement
Disease variantPalmoplantar keratoderma
Related Diseases
Biomarker
Investigative
Antibody