Protein detail

TXD11

Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1)

Entry name TXD11	UniProt ID Q6PKC3	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1)

Protein Class

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

65..85; Helical

Transmembrane Count

Ensembl

ENSG00000153066

Entrez Gene Symbol

TXNDC11

Gene Synonym

EFP1

Gene Description

Thioredoxin domain containing 11

Chromosome

Position

11679083-11742857

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificB-cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005789 endoplasmic reticulum membrane

Molecular Function

GO:0005515 protein binding

Biological Process

Reactome

Canonical Pathways

M120 Pid arf6 downstream pathway
M243 Pid arf 3pathway
M184 Pid ecadherin keratinocyte pathway

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EDEM2 TXNDC11 UHMK1	Q6PKC3 Q8TAS1 Q9BV94	0:0:0	hu.MAP2
	EDEM2 TXNDC11	Q6PKC3 Q9BV94	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	40189497 40985879 32916986 36146834 38207106

Sequence, Structure & Domains

Sequences

Length

985

Mass

110,529

Sequence

MSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKALESTSSPRALVSFTGEWHLETKIYVLDYLGTVRFGVITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVLNYTAENICKWALENQETLFRWLRPHGGKSLLLNNELKKGPALFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHLRRVDAPVLESLALEVPAQLPDPPTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTSGGMKPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVASDSIECSNFLTSYSPFSYYTACCRTISRGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDAPSSVPHIEENRYLFPEVDMTSTNFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAAIVDVKEESHYILDPKQALMKLTLESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSPQNVANSPTKECLQSEAVLQRGHISHLEREIQKLRAEISSLQRAQVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAHSEQLQALYEQKTRELQELARKLQELADASENLLTENTWLKILVATMERKLEGRDGAESLAAQREVHPKQPEPSATPQLPGSSPPPANVSATLVSERNKENRTD

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PKC3-1; Sequence=Displayed; Name=2; IsoId=Q6PKC3-2; Sequence=VSP_014335; Name=3; IsoId=Q6PKC3-3; Sequence=VSP_014336, VSP_014337

Alternative Sequence

265..291; Missing (in isoform 2); 265..278; ALESTSSPRALVSF -> DGVSPCRPGWSAVA (in isoform 3); 279..985; Missing (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

1..11; Gly residues; 29..38; Low complexity

Coiled Coil

821..919

Domain (FT)

92..214; Thioredoxin 1; 649..799; Thioredoxin 2

Region

1..38; Disordered; 935..985; Disordered

Protein Families

Protein disulfide isomerase family

Sequence Similarities

Belongs to the protein disulfide isomerase family.

Clinical Relevance

Antibody

HPA041174 HPA041390