Protein detail

TXD11

Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1)

Entry name TXD11	UniProt ID Q6PKC3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

65..85; Helical

Transmembrane Count

Ensembl

ENSG00000153066

Entrez Gene Symbol

TXNDC11

Gene Synonym

EFP1

Gene Description

Thioredoxin domain containing 11

Chromosome

Position

11679083-11742857

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificB-cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005789 endoplasmic reticulum membrane

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (3)

Canonical Pathways (3)

M120 Pid arf6 downstream pathway
M243 Pid arf 3pathway
M184 Pid ecadherin keratinocyte pathway

Mediation Categories

Metabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EDEM2 TXNDC11 UHMK1	Q6PKC3 Q8TAS1 Q9BV94	0:0:0	hu.MAP2
	EDEM2 TXNDC11	Q6PKC3 Q9BV94	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	40189497 40985879 32916986 36146834 38207106

Sequence, Structure & Domains11

Sequences

Length

985

Mass

110,529

Sequence

MSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKALESTSSPRALVSFTGEWHLETKIYVLDYLGTVRFGVITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVLNYTAENICKWALENQETLFRWLRPHGGKSLLLNNELKKGPALFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHLRRVDAPVLESLALEVPAQLPDPPTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTSGGMKPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVASDSIECSNFLTSYSPFSYYTACCRTISRGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDAPSSVPHIEENRYLFPEVDMTSTNFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAAIVDVKEESHYILDPKQALMKLTLESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSPQNVANSPTKECLQSEAVLQRGHISHLEREIQKLRAEISSLQRAQVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAHSEQLQALYEQKTRELQELARKLQELADASENLLTENTWLKILVATMERKLEGRDGAESLAAQREVHPKQPEPSATPQLPGSSPPPANVSATLVSERNKENRTD

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6PKC3-1; Sequence=Displayed; Name=2; IsoId=Q6PKC3-2; Sequence=VSP_014335; Name=3; IsoId=Q6PKC3-3; Sequence=VSP_014336, VSP_014337

Alternative Sequence

265..291; Missing (in isoform 2); 265..278; ALESTSSPRALVSF -> DGVSPCRPGWSAVA (in isoform 3); 279..985; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

1..11; Gly residues; 29..38; Low complexity

Coiled Coil

821..919

Domain (FT)

92..214; Thioredoxin 1; 649..799; Thioredoxin 2

Region

1..38; Disordered; 935..985; Disordered

Protein Families

Protein disulfide isomerase family

Sequence Similarities

Belongs to the protein disulfide isomerase family.

Clinical Relevance1

Antibody (2)

HPA041174 HPA041390

Supporting Publications1

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available