Protein detail

LCTL

Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)

Entry name LCTL	UniProt ID Q6UWM7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)

Protein Function

Cancer-related genes:Mutated cancer genes

Transmembrane

542..562; Helical

Transmembrane Count

Ensembl

ENSG00000188501

Entrez Gene Symbol

LCTL

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificadrenal glandCell SpecificAdrenal cortex cells

Function & Pathway5

Protein Function

Cancer-related genes:Mutated cancer genes

Cellular Component (2)

Molecular Function

GO:0008422 beta-glucosidase activity

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence20

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AGA LCTL PNP PXDNL	A1KZ92 P00491 P20933 Q6UWM7	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39363010

Sequence, Structure & Domains7

Sequences

Length

567

Mass

65,088

Sequence

MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVTEIVVPTVCSLCVLITAVLLMLLLRRQS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6UWM7-1; Sequence=Displayed; Name=2; IsoId=Q6UWM7-2; Sequence=VSP_054596

Alternative Sequence

1..173; Missing (in isoform 2)

Domain & Motif Annotations

Protein Families (2)

Glycosyl hydrolase 1 family
Klotho subfamily

Sequence Similarities

Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Supporting Publications1

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.