Protein detail

LCTL

Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)

Entry name
LCTL
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
1
Protein classification
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)
Protein Function
Cancer-related genes:Mutated cancer genes
Transmembrane
542..562; Helical
Transmembrane Count
1
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

18 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
cell_adhesioncell_adhesionCellinkerYesYesNoNoNo
adhesionadhesionOmniPathYesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembrane_predictedtransmembraneOmniPathNoNoNoNoNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
AGALCTLPNPPXDNLA1KZ92P00491P20933Q6UWM70:0:0:0hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry139363010
Sequence, Structure & Domains

Sequences

Length
567
Mass
65,088
Sequence
MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVTEIVVPTVCSLCVLITAVLLMLLLRRQS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6UWM7-1; Sequence=Displayed; Name=2; IsoId=Q6UWM7-2; Sequence=VSP_054596
Alternative Sequence
1..173; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Protein Families
  • Glycosyl hydrolase 1 family
  • Klotho subfamily
Sequence Similarities
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
Clinical Relevance