Protein detail

LCTL

Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)

Entry name LCTL	UniProt ID Q6UWM7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)

Protein Function

Cancer-related genes:Mutated cancer genes

Transmembrane

542..562; Helical

Transmembrane Count

Ensembl

ENSG00000188501

Entrez Gene Symbol

LCTL

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificadrenal glandCell SpecificAdrenal cortex cells

Function & Pathway5

Protein Function

Cancer-related genes:Mutated cancer genes

Cellular Component (2)

Molecular Function

GO:0008422 beta-glucosidase activity

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence20

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

Page 2 of 2Previous

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AGA LCTL PNP PXDNL	A1KZ92 P00491 P20933 Q6UWM7	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39363010

Sequence, Structure & Domains7

Sequences

Length

567

Mass

65,088

Sequence

MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVTEIVVPTVCSLCVLITAVLLMLLLRRQS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6UWM7-1; Sequence=Displayed; Name=2; IsoId=Q6UWM7-2; Sequence=VSP_054596

Alternative Sequence

1..173; Missing (in isoform 2)

Domain & Motif Annotations

Protein Families (2)

Glycosyl hydrolase 1 family
Klotho subfamily

Sequence Similarities

Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Supporting Publications1

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.