Protein detail
TM108
Transmembrane protein 108 (Retrolinkin)
Entry name TM108 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 4 | Transmembrane count 2 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Transmembrane protein 108 (Retrolinkin)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
9..29; Helical; 469..489; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CT124MGC3040
Gene Description
Transmembrane protein 108
Chromosome
3
Position
133038391-133397775
Supporting publications (n)
4
EVMP confidence score
0.28
Fluorescence & Localization
Tissue Specificfallopian tubeCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (10)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (3)
- M120 Pid arf6 downstream pathway
- M212 Pid integrin5 pathway
- M169 Pid integrin2 pathway
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence21
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane_predicted | transmembrane | OmniPath | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes |
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Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
575
Mass
59,948
Sequence
MKRSLQALYCQLLSFLLILALTEALAFAIQEPSPRESLQVLPSGTPPGTMVTAPHSSTRHTSVVMLTPNPDGPPSQAAAPMATPTPRAEGHPPTHTISTIAATVTAPHSESSLSTGPAPAAMATTSSKPEGRPRGQAAPTILLTKPPGATSRPTTAPPRTTTRRPPRPPGSSRKGAGNSSRPVPPAPGGHSRSKEGQRGRNPSSTPLGQKRPLGKIFQIYKGNFTGSVEPEPSTLTPRTPLWGYSSSPQPQTVAATTVPSNTSWAPTTTSLGPAKDKPGLRRAAQGGGSTFTSQGGTPDATAASGAPVSPQAAPVPSQRPHHGDPQDGPSHSDSWLTVTPGTSRPLSTSSGVFTAATGPTPAAFDTSVSAPSQGIPQGASTTPQAPTHPSRVSESTISGAKEETVATLTMTDRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHVAEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCMKRKKKTANPENNLSYWNNTITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6UXF1-1; Sequence=Displayed; Name=2; IsoId=Q6UXF1-2; Sequence=VSP_019494, VSP_019495
Alternative Sequence
485..487; VLL -> DPI (in isoform 2); 488..575; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
74..87; Low complexity; 95..115; Polar residues; 146..160; Low complexity; 244..271; Polar residues; 290..318; Low complexity; 329..352; Polar residues; 353..366; Low complexity; 367..398; Polar residues
Region
31..169; Interaction with SH3GL2; 65..398; Disordered; 173..407; Interaction with DST (isoform 1); 490..575; Interaction with CYFIP2
Clinical Relevance
Antibody
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 28680152 | Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity. | No related sentences available |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |