Protein detail
TM108
Transmembrane protein 108 (Retrolinkin)
Protein symbol TM108 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 2 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Transmembrane protein 108 (Retrolinkin)
Protein Class
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
9..29; Helical; 469..489; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym
CT124MGC3040
Gene Description
Transmembrane protein 108
Chromosome
3
Position
133038391-133397775
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificfallopian tubeCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M120 Pid arf6 downstream pathway
- M212 Pid integrin5 pathway
- M169 Pid integrin2 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
575
Mass
59,948
Sequence
MKRSLQALYCQLLSFLLILALTEALAFAIQEPSPRESLQVLPSGTPPGTMVTAPHSSTRHTSVVMLTPNPDGPPSQAAAPMATPTPRAEGHPPTHTISTIAATVTAPHSESSLSTGPAPAAMATTSSKPEGRPRGQAAPTILLTKPPGATSRPTTAPPRTTTRRPPRPPGSSRKGAGNSSRPVPPAPGGHSRSKEGQRGRNPSSTPLGQKRPLGKIFQIYKGNFTGSVEPEPSTLTPRTPLWGYSSSPQPQTVAATTVPSNTSWAPTTTSLGPAKDKPGLRRAAQGGGSTFTSQGGTPDATAASGAPVSPQAAPVPSQRPHHGDPQDGPSHSDSWLTVTPGTSRPLSTSSGVFTAATGPTPAAFDTSVSAPSQGIPQGASTTPQAPTHPSRVSESTISGAKEETVATLTMTDRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHVAEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCMKRKKKTANPENNLSYWNNTITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6UXF1-1; Sequence=Displayed; Name=2; IsoId=Q6UXF1-2; Sequence=VSP_019494, VSP_019495
Alternative Sequence
485..487; VLL -> DPI (in isoform 2); 488..575; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
74..87; Low complexity; 95..115; Polar residues; 146..160; Low complexity; 244..271; Polar residues; 290..318; Low complexity; 329..352; Polar residues; 353..366; Low complexity; 367..398; Polar residues
Region
31..169; Interaction with SH3GL2; 65..398; Disordered; 173..407; Interaction with DST (isoform 1); 490..575; Interaction with CYFIP2
Clinical Relevance
Antibody