Protein detail
GFRAL
GDNF family receptor alpha-like
Entry name GFRAL | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
GDNF family receptor alpha-like
Protein Class
Predicted membrane proteins
Transmembrane
352..371; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
bA360D14.1C6orf144GRALUNQ9356
Gene Description
GDNF family receptor alpha like
Chromosome
6
Position
55327469-55402493
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificlymphoid tissueCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway5
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Canonical Pathways (3)
- M252 Pid il8 cxcr1 pathway
- M213 Pid ar nongenomic pathway
- M210 Pid il8 cxcr2 pathway
Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence37
Ligand-Receptor Signaling (35)
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| cytokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| cytokine_tgf | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 21630462 |
Sequence, Structure & Domains10
Sequences
Length
394
Mass
44,518
Sequence
MIVFIFLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCKMRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKEDKFKWNLTTRSHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGNPCDLKQCQAAIRFFYQNIPFNIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCKAAYIDILGTVLQVQCTCRTITQSEESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGEVIYAAMCMTVTCGILLLVMVKLRTSRISSKARDPSSIQIPGEL
3D Structural Models
Turn
264..266; 281..284; 298..300
Helix
131..139; 142..154; 164..175; 180..188; 196..205; 208..211; 220..228; 231..244; 246..252; 256..260; 273..280; 286..288; 301..311; 313..315
Beta Strand
156..161
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Region
149..228; Required for interaction with GDF15
Protein Families
GDNFR family
Sequence Similarities
Belongs to the GDNFR family.