Protein detail
GFRAL
GDNF family receptor alpha-like
Protein symbol GFRAL | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
GDNF family receptor alpha-like
Protein Class
Predicted membrane proteins
Transmembrane
352..371; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
bA360D14.1C6orf144GRALUNQ9356
Gene Description
GDNF family receptor alpha like
Chromosome
6
Position
55327469-55402493
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M252 Pid il8 cxcr1 pathway
- M213 Pid ar nongenomic pathway
- M210 Pid il8 cxcr2 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 21630462 |
Sequence, Structure & Domains
Sequences
Length
394
Mass
44,518
Sequence
MIVFIFLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCKMRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKEDKFKWNLTTRSHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGNPCDLKQCQAAIRFFYQNIPFNIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCKAAYIDILGTVLQVQCTCRTITQSEESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGEVIYAAMCMTVTCGILLLVMVKLRTSRISSKARDPSSIQIPGEL
3D Structural Models
Turn
264..266; 281..284; 298..300
Helix
131..139; 142..154; 164..175; 180..188; 196..205; 208..211; 220..228; 231..244; 246..252; 256..260; 273..280; 286..288; 301..311; 313..315
Beta Strand
156..161
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Region
149..228; Required for interaction with GDF15
Protein Families
GDNFR family
Sequence Similarities
Belongs to the GDNFR family.