Protein detail

RHEX

Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein)

Entry name RHEX	UniProt ID Q6ZWK4	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein)

Transmembrane

9..29; Helical

Transmembrane Count

Ensembl

ENSG00000263961

Entrez Gene Symbol

RHEX

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway

Cellular Component

GO:0005886 plasma membrane

Molecular Function

Biological Process

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
RHEX SNX17 WDR47	O94967 Q15036 Q6ZWK4	0:0:0	hu.MAPhu.MAP2
ANGPTL4 ANKFY1 CADPS2 RHEX SAXO5 SNX17 WDR47	O94967 Q15036 Q6ZWK4 Q86UW7 Q8NA69 Q9BY76 Q9P2R3	0:0:0:0:0:0:0	hu.MAP2
FIGNL1 RHEX WDR47	O94967 Q6PIW4 Q6ZWK4	0:0:0	hu.MAP
ANGPTL4 CADPS2 RHEX SAXO5 WDR47	O94967 Q6ZWK4 Q86UW7 Q8NA69 Q9BY76	0:0:0:0:0	hu.MAP2
RHEX SNX17	Q15036 Q6ZWK4	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometryWestern blottingFlow cytometry	3	39363010 36114323 40595564

Sequence, Structure & Domains

Sequences

Length

172

Mass

19,405

Sequence

MLTEVMEVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVAM

3D Structural Models

Domain & Motif Annotations

Compositional Bias

64..89; Basic and acidic residues; 91..103; Low complexity

Region

52..106; Disordered

Clinical Relevance