Protein detail

RHEX

Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein)

Entry name RHEX	UniProt ID Q6ZWK4	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein)

Transmembrane

9..29; Helical

Transmembrane Count

Ensembl

ENSG00000263961

Entrez Gene Symbol

RHEX

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway4

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

Mediation Categories

Immune mediation

Relations & Evidence20

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

Page 2 of 2Previous

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
RHEX SNX17 WDR47	O94967 Q15036 Q6ZWK4	0:0:0	hu.MAPhu.MAP2
ANGPTL4 ANKFY1 CADPS2 RHEX SAXO5 SNX17 WDR47	O94967 Q15036 Q6ZWK4 Q86UW7 Q8NA69 Q9BY76 Q9P2R3	0:0:0:0:0:0:0	hu.MAP2
FIGNL1 RHEX WDR47	O94967 Q6PIW4 Q6ZWK4	0:0:0	hu.MAP
ANGPTL4 CADPS2 RHEX SAXO5 WDR47	O94967 Q6ZWK4 Q86UW7 Q8NA69 Q9BY76	0:0:0:0:0	hu.MAP2
RHEX SNX17	Q15036 Q6ZWK4	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometryWestern blottingFlow cytometry	3	39363010 36114323 40595564

Sequence, Structure & Domains5

Sequences

Length

172

Mass

19,405

Sequence

MLTEVMEVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVAM

Domain & Motif Annotations

Compositional Bias

64..89; Basic and acidic residues; 91..103; Low complexity

Region

52..106; Disordered

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available