Protein detail

TS1R3

Taste receptor type 1 member 3 (Sweet taste receptor T1R3)

Entry name TS1R3	UniProt ID Q7RTX0	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Taste receptor type 1 member 3 (Sweet taste receptor T1R3)

Protein Class

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function

G-protein coupled receptors:Family 3 (C) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

571..591; Helical; Name=1; 604..624; Helical; Name=2; 640..660; Helical; Name=3; 683..703; Helical; Name=4; 730..750; Helical; Name=5; 763..783; Helical; Name=6; 790..810; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000169962

Entrez Gene Symbol

TAS1R3

Gene Synonym

T1R3

Gene Description

Taste 1 receptor member 3

Chromosome

Position

1331280-1335314

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificEpicardial cells

Function & Pathway

Protein Function

G-protein coupled receptors:Family 3 (C) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

38 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
glutamate	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_c	receptor	HPMR	No	Yes	No	Yes	No
calcium_7tm_c	receptor	HPMR	No	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TAS1R2 TAS1R3	Q7RTX0 Q8TE23	1:1	PDB	PDB:9novPDB:9notPDB:9nosPDB:9norPDB:9nouPDB:9now

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer Precipitation	Mass spectrometryR Sequencing	4	39363010 40222457 34980157 40595564

Sequence, Structure & Domains

Sequences

Length

852

Mass

93,386

Sequence

MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQNDGNTGNQGKHE

3D Structural Models

3D Structure

Electron microscopy (7)

Domain & Motif Annotations

Region

536..545; Required for brazzein responsiveness

Protein Families

G-protein coupled receptor 3 family
TAS1R subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Clinical Relevance

Antibody

HPA053439