Protein detail
TS1R3
Taste receptor type 1 member 3 (Sweet taste receptor T1R3)
Entry name TS1R3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Taste receptor type 1 member 3 (Sweet taste receptor T1R3)
Protein Class
G-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- G-protein coupled receptors:Family 3 (C) receptors
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
571..591; Helical; Name=1; 604..624; Helical; Name=2; 640..660; Helical; Name=3; 683..703; Helical; Name=4; 730..750; Helical; Name=5; 763..783; Helical; Name=6; 790..810; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
T1R3
Gene Description
Taste 1 receptor member 3
Chromosome
1
Position
1331280-1335314
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificEpicardial cells
Function & Pathway
Protein Function
- G-protein coupled receptors:Family 3 (C) receptors
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| glutamate | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_c_glutamate | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_c_glutamate_sensory | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_c_glutamate_sensory_taste_1 | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
852
Mass
93,386
Sequence
MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQNDGNTGNQGKHE
3D Structural Models
3D Structure
Electron microscopy (7)
Domain & Motif Annotations
Region
536..545; Required for brazzein responsiveness
Protein Families
- G-protein coupled receptor 3 family
- TAS1R subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
Clinical Relevance
Antibody