Protein detail

NEGR1

Neuronal growth regulator 1 (IgLON family member 4)

Protein symbol NEGR1	UniProt ID Q7Z3B1	EVMP score 0.25
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted membrane proteins

Basic Information

Protein Names

Neuronal growth regulator 1 (IgLON family member 4)

Protein Class

Plasma proteinsPredicted membrane proteins

Ensembl

ENSG00000172260

Entrez Gene Symbol

NEGR1

Gene Synonym

IGLON4KILONMGC46680Ntra

Gene Description

Neuronal growth regulator 1

Chromosome

Position

71395943-72282539

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificBasal keratinocytesSingle-Nuclei Brain Specificependymal cell

Function & Pathway

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

KEGG

hsa04514 Cell adhesion molecule (CAM) interaction

Reactome

Mediation Categories

Metabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	Yes
receptor	receptor	Baccin2019	No	Yes	No	Yes	Yes
receptor	receptor	OmniPath	No	Yes	No	Yes	Yes
extracellular	extracellular	OmniPath	No	No	No	Yes	Yes
intracellular	intracellular	ComPPI	No	No	No	Yes	Yes
intracellular	intracellular	GO_Intercell	No	No	No	Yes	Yes
intracellular	intracellular	OmniPath	No	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	Yes

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IGLON5 NEGR1	A6NGN9 Q7Z3B1	2:2	PDB	PDB:6dld
	NEGR1	Q7Z3B1	2	PDB	PDB:6u6t

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometryR Sequencing	2	28211531 31414377

Sequence, Structure & Domains

Sequences

Length

354

Mass

38,719

Sequence

MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z3B1-1; Sequence=Displayed; Name=2; IsoId=Q7Z3B1-2; Sequence=VSP_056313

Alternative Sequence

1..128; Missing (in isoform 2)

3D Structural Models

Helix

110..112; 195..197; 289..291

Beta Strand

47..49; 56..58; 64..66; 69..73; 76..80; 91..94; 102..105; 114..120; 123..125; 131..134; 137..144; 148..151; 156..166; 169..178; 184..192; 199..206; 208..211; 213..232; 241..251; 254..259; 267..270; 271..275; 277..286; 293..300; 305..312

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

38..134; Ig-like C2-type 1; 139..221; Ig-like C2-type 2; 225..313; Ig-like C2-type 3

Protein Families

Immunoglobulin superfamily
IgLON family

Sequence Similarities

Belongs to the immunoglobulin superfamily. IgLON family.

Clinical Relevance

Antibody

HPA011894