Protein detail

NEGR1

Neuronal growth regulator 1 (IgLON family member 4)

Entry name NEGR1	UniProt ID Q7Z3B1	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Neuronal growth regulator 1 (IgLON family member 4)

Protein Class (2)

Plasma proteinsPredicted membrane proteins

Ensembl

ENSG00000172260

Entrez Gene Symbol

NEGR1

Gene Synonym (4)

IGLON4KILONMGC46680Ntra

Gene Description

Neuronal growth regulator 1

Chromosome

Position

71395943-72282539

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Cell SpecificBasal keratinocytesSingle-Nuclei Brain Specificependymal cell

Function & Pathway6

Cellular Component (6)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG

hsa04514 Cell adhesion molecule (CAM) interaction

Reactome (2)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence40

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
iglon	cell_adhesion	HGNC	Yes	Yes	No	Yes	Yes
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	Yes
adhesion	adhesion	MCAM	Yes	Yes	No	Yes	Yes
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	Yes
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	Yes
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	Yes
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	Yes
transmembrane	transmembrane	TopDB	No	No	No	Yes	Yes
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	Yes

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IGLON5 NEGR1	A6NGN9 Q7Z3B1	2:2	PDB	PDB:6dld
	NEGR1	Q7Z3B1	2	PDB	PDB:6u6t

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometryR Sequencing	2	28211531 31414377

Sequence, Structure & Domains11

Sequences

Length

354

Mass

38,719

Sequence

MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z3B1-1; Sequence=Displayed; Name=2; IsoId=Q7Z3B1-2; Sequence=VSP_056313

Alternative Sequence

1..128; Missing (in isoform 2)

3D Structural Models

Helix

110..112; 195..197; 289..291

Beta Strand

47..49; 56..58; 64..66; 69..73; 76..80; 91..94; 102..105; 114..120; 123..125; 131..134; 137..144; 148..151; 156..166; 169..178; 184..192; 199..206; 208..211; 213..232; 241..251; 254..259; 267..270; 271..275; 277..286; 293..300; 305..312

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

38..134; Ig-like C2-type 1; 139..221; Ig-like C2-type 2; 225..313; Ig-like C2-type 3

Protein Families (2)

Immunoglobulin superfamily
IgLON family

Sequence Similarities

Belongs to the immunoglobulin superfamily. IgLON family.

Clinical Relevance1

Antibody

HPA011894

Supporting Publications1

PMID	Title	Abstract
36631006	MicroRNA-155-5p in serum derived-exosomes promotes ischaemia-reperfusion injury by reducing CypD ubiquitination by NEDD4.	No abstract available