Protein detail

S46A3

Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)

Entry name
S46A3
UniProt ID
Q7Z3Q1
EVMP score
0.50
Frequency
1
Transmembrane count
11
Protein classification
Predicted membrane proteinsTransporters
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
74..94; Helical; 102..124; Helical; 134..156; Helical; 171..191; Helical; 198..218; Helical; 262..282; Helical; 295..315; Helical; 325..345; Helical; 348..368; Helical; 383..403; Helical; 416..436; Helical
Transmembrane Count
11
Ensembl
ENSG00000139508
Entrez Gene Symbol
SLC46A3
Gene Synonym
DKFZp686A1775FLJ42613
Gene Description
Solute carrier family 46 member 3
Chromosome
13
Position
28700064-28718970
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificmonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

20 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
transportertransporterSurfaceomeNoYesNoNoNo
solute_carriertransporterAlmen2009NoYesNoNoNo
mfstransporterSurfaceomeNoYesNoNoNo
slctransporterSurfaceomeNoYesNoNoNo
slc46transporterSurfaceomeNoYesNoNoNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometryWestern blottingMass spectrometry [QTOF]Western blotting|Mass spectrometryMORPHELISA432944195342956533499237134992371
Sequence, Structure & Domains

Sequences

Length
461
Mass
51,519
Sequence
MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z3Q1-1; Sequence=Displayed; Name=2; IsoId=Q7Z3Q1-2; Sequence=VSP_028649; Name=3; IsoId=Q7Z3Q1-3; Sequence=VSP_028648
Alternative Sequence
1..75; Missing (in isoform 3); 461; R -> RAC (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Motif
446..449; Tyrosine-based lysosomal-sorting motif
Protein Families
  • Major facilitator superfamily
  • SLC46A family
Sequence Similarities
Belongs to the major facilitator superfamily. SLC46A family.
Clinical Relevance
Antibody
HPA039930