Protein detail

S46A3

Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)

Entry name S46A3	UniProt ID Q7Z3Q1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 11	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

74..94; Helical; 102..124; Helical; 134..156; Helical; 171..191; Helical; 198..218; Helical; 262..282; Helical; 295..315; Helical; 325..345; Helical; 348..368; Helical; 383..403; Helical; 416..436; Helical

Transmembrane Count

Ensembl

ENSG00000139508

Entrez Gene Symbol

SLC46A3

Gene Synonym (2)

DKFZp686A1775FLJ42613

Gene Description

Solute carrier family 46 member 3

Chromosome

Position

28700064-28718970

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificmonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence21

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
mfs	transporter	Surfaceome	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No
slc46	transporter	Surfaceome	No	Yes	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingMass spectrometry [QTOF]Western blotting\|Mass spectrometryMORPHELISA	4	32944195 34295653 34992371 34992371

Sequence, Structure & Domains8

Sequences

Length

461

Mass

51,519

Sequence

MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z3Q1-1; Sequence=Displayed; Name=2; IsoId=Q7Z3Q1-2; Sequence=VSP_028649; Name=3; IsoId=Q7Z3Q1-3; Sequence=VSP_028648

Alternative Sequence

1..75; Missing (in isoform 3); 461; R -> RAC (in isoform 2)

Domain & Motif Annotations

Motif

446..449; Tyrosine-based lysosomal-sorting motif

Protein Families (2)

Major facilitator superfamily
SLC46A family

Sequence Similarities

Belongs to the major facilitator superfamily. SLC46A family.

Clinical Relevance1

Antibody

HPA039930

Supporting Publications1

PMID	Title	Abstract
36741391	Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients.	We have also shown that immuno-oncological proteins isolated from pre-ICIs treated patients were significantly higher in exosomes compared to their soluble-free counterparts (CD152, p=0.0008; CD80, p=0.0182; IDO, p=0.0443; Arginase, p<0.0001; Nectin-2, p<0.0001; NT5E, p<0.0001; Siglec-7, p<0.0001; Siglec-9, p=0.0335; CD28, p=0.0092; GITR, p<0.0001; MICA, p<0.0001).