Protein detail
S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)
Entry name S46A3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 11 | Protein classification Predicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
74..94; Helical; 102..124; Helical; 134..156; Helical; 171..191; Helical; 198..218; Helical; 262..282; Helical; 295..315; Helical; 325..345; Helical; 348..368; Helical; 383..403; Helical; 416..436; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp686A1775FLJ42613
Gene Description
Solute carrier family 46 member 3
Chromosome
13
Position
28700064-28718970
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificmonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 2 of 2Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
461
Mass
51,519
Sequence
MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z3Q1-1; Sequence=Displayed; Name=2; IsoId=Q7Z3Q1-2; Sequence=VSP_028649; Name=3; IsoId=Q7Z3Q1-3; Sequence=VSP_028648
Alternative Sequence
1..75; Missing (in isoform 3); 461; R -> RAC (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Motif
446..449; Tyrosine-based lysosomal-sorting motif
Protein Families
- Major facilitator superfamily
- SLC46A family
Sequence Similarities
Belongs to the major facilitator superfamily. SLC46A family.
Clinical Relevance
Antibody