Protein detail
PRRT2
Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
Entry name PRRT2 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
Protein Class (6)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (6)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
318..338; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (9)
DKFZp547J199DSPB3DYT10EKD1FICCAFLJ25513ICCAIFITMD1PKC
Gene Description
Proline rich transmembrane protein 2
Chromosome
16
Position
29811382-29815892
Supporting publications (n)
5
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificRenal collecting duct intercalated cellsSingle-Nuclei Brain Specificmammillary body
Function & Pathway
Protein Function (6)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component (11)
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0016020 membrane
- GO:0030672 synaptic vesicle membrane
- GO:0031982 vesicle
- GO:0042734 presynaptic membrane
- GO:0043197 dendritic spine
- GO:0043679 axon terminus
- GO:0098793 presynapse
- GO:0098839 postsynaptic density membrane
Page 1 of 2
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence15
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| peripheral | peripheral | UniProt_topology |
Page 1 of 2Next
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
340
Mass
34,945
Sequence
MAASSSEISEMKGVEESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z6L0-1; Sequence=Displayed; Name=2; IsoId=Q7Z6L0-2; Sequence=VSP_028815; Name=3; IsoId=Q7Z6L0-3; Sequence=VSP_028814
Alternative Sequence
294..340; SRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK -> VSPMGP (in isoform 3); 337; G -> GGEWGLGTGRGGMEGLARAALLTPAPALSCLSSLPLLCLSLSPPPPVCPSLSSPT (in isoform 2)
Domain & Motif Annotations
Compositional Bias
9..18; Basic and acidic residues; 131..155; Pro residues; 197..207; Pro residues
Region
1..261; Disordered
Protein Families
CD225/Dispanin family
Sequence Similarities
Belongs to the CD225/Dispanin family.
Clinical Relevance
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 38343172 | Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles. | No related sentences available |
| 39025337 | Shotgun proteomics of thyroid carcinoma exosomes - Insight into the role of exosomal proteins in carcinogenesis and thyroid homeostasis. | No related sentences available |
| 39363010 | Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons. | No related sentences available |
| 40222457 | Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement. | No related sentences available |
| 40595564 | Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome. | No related sentences available |