Protein detail
PRRT2
Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
Protein symbol PRRT2 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
318..338; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp547J199DSPB3DYT10EKD1FICCAFLJ25513ICCAIFITMD1PKC
Gene Description
Proline rich transmembrane protein 2
Chromosome
16
Position
29811382-29815892
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificRenal collecting duct intercalated cellsSingle-Nuclei Brain Specificmammillary body
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0016020 membrane
- GO:0030672 synaptic vesicle membrane
- GO:0031982 vesicle
- GO:0042734 presynaptic membrane
- GO:0043197 dendritic spine
- GO:0043679 axon terminus
- GO:0098793 presynapse
- GO:0098839 postsynaptic density membrane
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
340
Mass
34,945
Sequence
MAASSSEISEMKGVEESPKVPGEGPGHSEAETGPPQVLAGVPDQPEAPQPGPNTTAAPVDSGPKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGAVVPLQAGDGEEGPAPEPHSPPSKKSPPANGAPPRVLQQLVEEDRMRRAHSGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z6L0-1; Sequence=Displayed; Name=2; IsoId=Q7Z6L0-2; Sequence=VSP_028815; Name=3; IsoId=Q7Z6L0-3; Sequence=VSP_028814
Alternative Sequence
294..340; SRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK -> VSPMGP (in isoform 3); 337; G -> GGEWGLGTGRGGMEGLARAALLTPAPALSCLSSLPLLCLSLSPPPPVCPSLSSPT (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
9..18; Basic and acidic residues; 131..155; Pro residues; 197..207; Pro residues
Region
1..261; Disordered
Protein Families
CD225/Dispanin family
Sequence Similarities
Belongs to the CD225/Dispanin family.
Clinical Relevance
Disease Involvement
Disease variantDystoniaEpilepsy
Drugs