Protein detail
S22AG
Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)
Protein symbol S22AG | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
23..43; Helical; 152..172; Helical; 183..203; Helical; 214..234; Helical; 244..264; Helical; 268..288; Helical; 359..379; Helical; 389..409; Helical; 416..436; Helical; 441..461; Helical; 476..496; Helical; 501..521; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
CT2FLIPT2OAT6OKB1
Gene Description
Solute carrier family 22 member 16
Chromosome
6
Position
110424687-110476641
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificB-cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | Yes | No |
| mfs | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc22 | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc | transporter | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACSM1APBA3NFX1PDHA2SLC22A16 | O96018P29803Q08AH1Q12986Q86VW1 | 0:0:0:0:0 | hu.MAP2 | |||
| ACSM1GBP5SLC22A16 | Q08AH1Q86VW1Q96PP8 | 0:0:0 | hu.MAP2 | |||
| ACSM1CPEB1GBP5SLC22A16 | Q08AH1Q86VW1Q96PP8Q9BZB8 | 0:0:0:0 | hu.MAP2 | |||
| GBP5SLC22A16 | Q86VW1Q96PP8 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
Sequence, Structure & Domains
Sequences
Length
577
Mass
64,614
Sequence
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86VW1-1; Sequence=Displayed; Name=2; IsoId=Q86VW1-2; Sequence=VSP_031336, VSP_031337; Name=3; IsoId=Q86VW1-3; Sequence=VSP_031338
Alternative Sequence
1..17; MGSRHFEGIYDHVGHFG -> MRTLHAVSHPYSNSM (in isoform 2); 58..89; Missing (in isoform 2); 509..577; FVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE -> LGQHLQE (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
551..560; Low complexity
Region
543..577; Disordered
Protein Families
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance
Drugs
Antibody